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Flare of Antiphospholipid Syndrome in the Course of COVID-19

We report the case of a 48-year-old man followed since 2013 for primary antiphospholipid syndrome (APLS) revealed by venous thromboembolism in the presence of antiphospholipid antibodies (APL-Abs, anticardiolipin and anti-β-2-glycoprotein-1), who decompensated in the course of coronavirus disease (C...

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Autores principales: Maria, Alexandre Thibault Jacques, Diaz-Cau, Isabelle, Benejean, Jean-Marc, Nutz, Anaïs, Schiffmann, Aurélie, Biron-Andreani, Christine, Guilpain, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486139/
https://www.ncbi.nlm.nih.gov/pubmed/32935073
http://dx.doi.org/10.1055/s-0040-1716735
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author Maria, Alexandre Thibault Jacques
Diaz-Cau, Isabelle
Benejean, Jean-Marc
Nutz, Anaïs
Schiffmann, Aurélie
Biron-Andreani, Christine
Guilpain, Philippe
author_facet Maria, Alexandre Thibault Jacques
Diaz-Cau, Isabelle
Benejean, Jean-Marc
Nutz, Anaïs
Schiffmann, Aurélie
Biron-Andreani, Christine
Guilpain, Philippe
author_sort Maria, Alexandre Thibault Jacques
collection PubMed
description We report the case of a 48-year-old man followed since 2013 for primary antiphospholipid syndrome (APLS) revealed by venous thromboembolism in the presence of antiphospholipid antibodies (APL-Abs, anticardiolipin and anti-β-2-glycoprotein-1), who decompensated in the course of coronavirus disease (COVID-19). Despite efficient anticoagulation, he suffered bilateral adrenal glands hemorrhage and limb arterial ischemia. The tropism of severe acute respiratory syndrome coronavirus-2 for endothelium can lead to microangiopathy and increased risk for thrombosis. If APL-Abs positivity can be an epiphenomenon under inflammatory and prothrombotic conditions, COVID-19 was herein responsible for disseminated thrombosis and a threat of catastrophic APLS, despite efficient anticoagulation.
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spelling pubmed-74861392020-09-14 Flare of Antiphospholipid Syndrome in the Course of COVID-19 Maria, Alexandre Thibault Jacques Diaz-Cau, Isabelle Benejean, Jean-Marc Nutz, Anaïs Schiffmann, Aurélie Biron-Andreani, Christine Guilpain, Philippe TH Open We report the case of a 48-year-old man followed since 2013 for primary antiphospholipid syndrome (APLS) revealed by venous thromboembolism in the presence of antiphospholipid antibodies (APL-Abs, anticardiolipin and anti-β-2-glycoprotein-1), who decompensated in the course of coronavirus disease (COVID-19). Despite efficient anticoagulation, he suffered bilateral adrenal glands hemorrhage and limb arterial ischemia. The tropism of severe acute respiratory syndrome coronavirus-2 for endothelium can lead to microangiopathy and increased risk for thrombosis. If APL-Abs positivity can be an epiphenomenon under inflammatory and prothrombotic conditions, COVID-19 was herein responsible for disseminated thrombosis and a threat of catastrophic APLS, despite efficient anticoagulation. Georg Thieme Verlag KG 2020-09-11 /pmc/articles/PMC7486139/ /pubmed/32935073 http://dx.doi.org/10.1055/s-0040-1716735 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ). https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Maria, Alexandre Thibault Jacques
Diaz-Cau, Isabelle
Benejean, Jean-Marc
Nutz, Anaïs
Schiffmann, Aurélie
Biron-Andreani, Christine
Guilpain, Philippe
Flare of Antiphospholipid Syndrome in the Course of COVID-19
title Flare of Antiphospholipid Syndrome in the Course of COVID-19
title_full Flare of Antiphospholipid Syndrome in the Course of COVID-19
title_fullStr Flare of Antiphospholipid Syndrome in the Course of COVID-19
title_full_unstemmed Flare of Antiphospholipid Syndrome in the Course of COVID-19
title_short Flare of Antiphospholipid Syndrome in the Course of COVID-19
title_sort flare of antiphospholipid syndrome in the course of covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486139/
https://www.ncbi.nlm.nih.gov/pubmed/32935073
http://dx.doi.org/10.1055/s-0040-1716735
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