Molecular phylogeny and missense mutations at envelope proteins across coronaviruses

Envelope (E) protein is one of the structural viroporins (76–109 amino acids long) present in the coronavirus. Sixteen sequentially different E-proteins were observed from a total of 4917 available complete SARS-CoV-2 genomes as on 18th June 2020 in the NCBI database. The missense mutations over the...

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Autores principales: Hassan, Sk. Sarif, Choudhury, Pabitra Pal, Roy, Bidyut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486180/
https://www.ncbi.nlm.nih.gov/pubmed/32927009
http://dx.doi.org/10.1016/j.ygeno.2020.09.014
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author Hassan, Sk. Sarif
Choudhury, Pabitra Pal
Roy, Bidyut
author_facet Hassan, Sk. Sarif
Choudhury, Pabitra Pal
Roy, Bidyut
author_sort Hassan, Sk. Sarif
collection PubMed
description Envelope (E) protein is one of the structural viroporins (76–109 amino acids long) present in the coronavirus. Sixteen sequentially different E-proteins were observed from a total of 4917 available complete SARS-CoV-2 genomes as on 18th June 2020 in the NCBI database. The missense mutations over the envelope protein across various coronaviruses of the β-genus were analyzed to know the immediate parental origin of the envelope protein of SARS-CoV-2. The evolutionary origin is also endorsed by the phylogenetic analysis of the envelope proteins comparing sequence homology as well as amino acid conservations.
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spelling pubmed-74861802020-09-14 Molecular phylogeny and missense mutations at envelope proteins across coronaviruses Hassan, Sk. Sarif Choudhury, Pabitra Pal Roy, Bidyut Genomics Article Envelope (E) protein is one of the structural viroporins (76–109 amino acids long) present in the coronavirus. Sixteen sequentially different E-proteins were observed from a total of 4917 available complete SARS-CoV-2 genomes as on 18th June 2020 in the NCBI database. The missense mutations over the envelope protein across various coronaviruses of the β-genus were analyzed to know the immediate parental origin of the envelope protein of SARS-CoV-2. The evolutionary origin is also endorsed by the phylogenetic analysis of the envelope proteins comparing sequence homology as well as amino acid conservations. Elsevier Inc. 2020-11 2020-09-12 /pmc/articles/PMC7486180/ /pubmed/32927009 http://dx.doi.org/10.1016/j.ygeno.2020.09.014 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hassan, Sk. Sarif
Choudhury, Pabitra Pal
Roy, Bidyut
Molecular phylogeny and missense mutations at envelope proteins across coronaviruses
title Molecular phylogeny and missense mutations at envelope proteins across coronaviruses
title_full Molecular phylogeny and missense mutations at envelope proteins across coronaviruses
title_fullStr Molecular phylogeny and missense mutations at envelope proteins across coronaviruses
title_full_unstemmed Molecular phylogeny and missense mutations at envelope proteins across coronaviruses
title_short Molecular phylogeny and missense mutations at envelope proteins across coronaviruses
title_sort molecular phylogeny and missense mutations at envelope proteins across coronaviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486180/
https://www.ncbi.nlm.nih.gov/pubmed/32927009
http://dx.doi.org/10.1016/j.ygeno.2020.09.014
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