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Respiratory disease in rhesus macaques inoculated with SARS-CoV-2
An outbreak of a novel coronavirus, named SARS-CoV-2, causing respiratory disease and a ~2% case fatality rate started in Wuhan, China in December 2019(1,2). Following unprecedented global spread3, the World Health Organization declared COVID-19 a pandemic on March 11, 2020. Although data on disease...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486227/ https://www.ncbi.nlm.nih.gov/pubmed/32396922 http://dx.doi.org/10.1038/s41586-020-2324-7 |
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author | Munster, Vincent J. Feldmann, Friederike Williamson, Brandi N. van Doremalen, Neeltje Pérez-Pérez, Lizzette Schulz, Jonathan Meade-White, Kimberly Okumura, Atsushi Callison, Julie Brumbaugh, Beniah Avanzato, Victoria A. Rosenke, Rebecca Hanley, Patrick W. Saturday, Greg Scott, Dana Fischer, Elizabeth R. de Wit, Emmie |
author_facet | Munster, Vincent J. Feldmann, Friederike Williamson, Brandi N. van Doremalen, Neeltje Pérez-Pérez, Lizzette Schulz, Jonathan Meade-White, Kimberly Okumura, Atsushi Callison, Julie Brumbaugh, Beniah Avanzato, Victoria A. Rosenke, Rebecca Hanley, Patrick W. Saturday, Greg Scott, Dana Fischer, Elizabeth R. de Wit, Emmie |
author_sort | Munster, Vincent J. |
collection | PubMed |
description | An outbreak of a novel coronavirus, named SARS-CoV-2, causing respiratory disease and a ~2% case fatality rate started in Wuhan, China in December 2019(1,2). Following unprecedented global spread3, the World Health Organization declared COVID-19 a pandemic on March 11, 2020. Although data on disease in humans are emerging at a steady pace, certain aspects of the pathogenesis of SARS-CoV-2 can only be studied in detail in animal models, where repeated sampling and tissue collection is possible. Here, we show that SARS-CoV-2 causes respiratory disease in infected rhesus macaques, with disease lasting 8–16 days. Pulmonary infiltrates, a hallmark of human disease, were visible in lung radiographs. High viral loads were detected in swabs from the nose and throat of all animals as well as in bronchoalveolar lavages; in one animal we observed prolonged rectal shedding. Taken together, the rhesus macaque recapitulates moderate disease observed in the majority of human cases. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease and will aid development and testing of medical countermeasures. |
format | Online Article Text |
id | pubmed-7486227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-74862272020-11-12 Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 Munster, Vincent J. Feldmann, Friederike Williamson, Brandi N. van Doremalen, Neeltje Pérez-Pérez, Lizzette Schulz, Jonathan Meade-White, Kimberly Okumura, Atsushi Callison, Julie Brumbaugh, Beniah Avanzato, Victoria A. Rosenke, Rebecca Hanley, Patrick W. Saturday, Greg Scott, Dana Fischer, Elizabeth R. de Wit, Emmie Nature Article An outbreak of a novel coronavirus, named SARS-CoV-2, causing respiratory disease and a ~2% case fatality rate started in Wuhan, China in December 2019(1,2). Following unprecedented global spread3, the World Health Organization declared COVID-19 a pandemic on March 11, 2020. Although data on disease in humans are emerging at a steady pace, certain aspects of the pathogenesis of SARS-CoV-2 can only be studied in detail in animal models, where repeated sampling and tissue collection is possible. Here, we show that SARS-CoV-2 causes respiratory disease in infected rhesus macaques, with disease lasting 8–16 days. Pulmonary infiltrates, a hallmark of human disease, were visible in lung radiographs. High viral loads were detected in swabs from the nose and throat of all animals as well as in bronchoalveolar lavages; in one animal we observed prolonged rectal shedding. Taken together, the rhesus macaque recapitulates moderate disease observed in the majority of human cases. The establishment of the rhesus macaque as a model of COVID-19 will increase our understanding of the pathogenesis of this disease and will aid development and testing of medical countermeasures. 2020-05-12 2020-09 /pmc/articles/PMC7486227/ /pubmed/32396922 http://dx.doi.org/10.1038/s41586-020-2324-7 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Munster, Vincent J. Feldmann, Friederike Williamson, Brandi N. van Doremalen, Neeltje Pérez-Pérez, Lizzette Schulz, Jonathan Meade-White, Kimberly Okumura, Atsushi Callison, Julie Brumbaugh, Beniah Avanzato, Victoria A. Rosenke, Rebecca Hanley, Patrick W. Saturday, Greg Scott, Dana Fischer, Elizabeth R. de Wit, Emmie Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 |
title | Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 |
title_full | Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 |
title_fullStr | Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 |
title_full_unstemmed | Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 |
title_short | Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 |
title_sort | respiratory disease in rhesus macaques inoculated with sars-cov-2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486227/ https://www.ncbi.nlm.nih.gov/pubmed/32396922 http://dx.doi.org/10.1038/s41586-020-2324-7 |
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