The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Molecular glue compounds induce protein-protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation.(1) Unlike traditional enzyme inhibitors, such molecular glue degraders act sub-stoichiometrically to catalyse rapid depletion of previously inaccessible targets.(2) T...

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Detalles Bibliográficos
Autores principales: Słabicki, Mikołaj, Kozicka, Zuzanna, Petzold, Georg, Li, Yen-Der, Manojkumar, Manisha, Bunker, Richard, Donovan, Katherine A., Sievers, Quinlan L., Koeppel, Jonas, Suchyta, Dakota, Sperling, Adam S., Fink, Emma C., Gasser, Jessica A., Wang, Li R., Corsello, Steven M., Sellar, Rob S., Jan, Max, Gillingham, Dennis, Scholl, Claudia, Fröhling, Stefan, Golub, Todd R., Fischer, Eric S., Thomä, Nicolas H., Ebert, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486275/
https://www.ncbi.nlm.nih.gov/pubmed/32494016
http://dx.doi.org/10.1038/s41586-020-2374-x

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