A Single Metabolite which Modulates Lipid Metabolism Alters Hematopoietic Stem/Progenitor Cell Behavior and Promotes Lymphoid Reconstitution

Fatty acid β-oxidation (FAO), the breakdown of lipids, is a metabolic pathway used by various stem cells. FAO levels are generally high during quiescence and downregulated with proliferation. The endogenous metabolite malonyl-CoA modulates lipid metabolism as a reversible FAO inhibitor and as a subs...

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Detalles Bibliográficos
Autores principales: Giger, Sonja, Kovtonyuk, Larisa V., Utz, Sebastian G., Ramosaj, Mergim, Kovacs, Werner J., Schmid, Emanuel, Ioannidis, Vassilios, Greter, Melanie, Manz, Markus G., Lutolf, Matthias P., Jessberger, Sebastian, Knobloch, Marlen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486304/
https://www.ncbi.nlm.nih.gov/pubmed/32857979
http://dx.doi.org/10.1016/j.stemcr.2020.07.021

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