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Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

TGF-β1, β2 and β3 bind a common receptor to exert vastly diverse effects in cancer, supporting either tumor progression by favoring metastases and inhibiting anti-tumor immunity, or tumor suppression by inhibiting malignant cell proliferation. Global TGF-β inhibition thus bears the risk of undesired...

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Detalles Bibliográficos
Autores principales:	de Streel, Grégoire, Bertrand, Charlotte, Chalon, Nicolas, Liénart, Stéphanie, Bricard, Orian, Lecomte, Sara, Devreux, Julien, Gaignage, Mélanie, De Boeck, Gitte, Mariën, Lore, Van De Walle, Inge, van der Woning, Bas, Saunders, Michael, de Haard, Hans, Vermeersch, Elien, Maes, Wim, Deckmyn, Hans, Coulie, Pierre G., van Baren, Nicolas, Lucas, Sophie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486376/ https://www.ncbi.nlm.nih.gov/pubmed/32917858 http://dx.doi.org/10.1038/s41467-020-17811-3

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