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Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus

Place cells exhibit spatially selective firing fields that collectively map the continuum of positions in environments; how such activity pattern develops with experience is largely unknown. Here, we record putative granule cells (GCs) and mossy cells (MCs) from the dentate gyrus (DG) over 27 days a...

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Autores principales: Kim, Soyoun, Jung, Dajung, Royer, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486408/
https://www.ncbi.nlm.nih.gov/pubmed/32917862
http://dx.doi.org/10.1038/s41467-020-18351-6
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author Kim, Soyoun
Jung, Dajung
Royer, Sébastien
author_facet Kim, Soyoun
Jung, Dajung
Royer, Sébastien
author_sort Kim, Soyoun
collection PubMed
description Place cells exhibit spatially selective firing fields that collectively map the continuum of positions in environments; how such activity pattern develops with experience is largely unknown. Here, we record putative granule cells (GCs) and mossy cells (MCs) from the dentate gyrus (DG) over 27 days as mice repetitively run through a sequence of objects fixed onto a treadmill belt. We observe a progressive transformation of GC spatial representations, from a sparse encoding of object locations and spatial patterns to increasingly more single, evenly dispersed place fields, while MCs show little transformation and preferentially encode object locations. A competitive learning model of the DG reproduces GC transformations via the progressive integration of landmark-vector cells and spatial inputs and requires MC-mediated feedforward inhibition to evenly distribute GC representations, suggesting that GCs slowly encode conjunctions of objects and spatial information via competitive learning, while MCs help homogenize GC spatial representations.
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spelling pubmed-74864082020-09-25 Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus Kim, Soyoun Jung, Dajung Royer, Sébastien Nat Commun Article Place cells exhibit spatially selective firing fields that collectively map the continuum of positions in environments; how such activity pattern develops with experience is largely unknown. Here, we record putative granule cells (GCs) and mossy cells (MCs) from the dentate gyrus (DG) over 27 days as mice repetitively run through a sequence of objects fixed onto a treadmill belt. We observe a progressive transformation of GC spatial representations, from a sparse encoding of object locations and spatial patterns to increasingly more single, evenly dispersed place fields, while MCs show little transformation and preferentially encode object locations. A competitive learning model of the DG reproduces GC transformations via the progressive integration of landmark-vector cells and spatial inputs and requires MC-mediated feedforward inhibition to evenly distribute GC representations, suggesting that GCs slowly encode conjunctions of objects and spatial information via competitive learning, while MCs help homogenize GC spatial representations. Nature Publishing Group UK 2020-09-11 /pmc/articles/PMC7486408/ /pubmed/32917862 http://dx.doi.org/10.1038/s41467-020-18351-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Soyoun
Jung, Dajung
Royer, Sébastien
Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
title Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
title_full Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
title_fullStr Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
title_full_unstemmed Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
title_short Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
title_sort place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486408/
https://www.ncbi.nlm.nih.gov/pubmed/32917862
http://dx.doi.org/10.1038/s41467-020-18351-6
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