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Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus
Place cells exhibit spatially selective firing fields that collectively map the continuum of positions in environments; how such activity pattern develops with experience is largely unknown. Here, we record putative granule cells (GCs) and mossy cells (MCs) from the dentate gyrus (DG) over 27 days a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486408/ https://www.ncbi.nlm.nih.gov/pubmed/32917862 http://dx.doi.org/10.1038/s41467-020-18351-6 |
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author | Kim, Soyoun Jung, Dajung Royer, Sébastien |
author_facet | Kim, Soyoun Jung, Dajung Royer, Sébastien |
author_sort | Kim, Soyoun |
collection | PubMed |
description | Place cells exhibit spatially selective firing fields that collectively map the continuum of positions in environments; how such activity pattern develops with experience is largely unknown. Here, we record putative granule cells (GCs) and mossy cells (MCs) from the dentate gyrus (DG) over 27 days as mice repetitively run through a sequence of objects fixed onto a treadmill belt. We observe a progressive transformation of GC spatial representations, from a sparse encoding of object locations and spatial patterns to increasingly more single, evenly dispersed place fields, while MCs show little transformation and preferentially encode object locations. A competitive learning model of the DG reproduces GC transformations via the progressive integration of landmark-vector cells and spatial inputs and requires MC-mediated feedforward inhibition to evenly distribute GC representations, suggesting that GCs slowly encode conjunctions of objects and spatial information via competitive learning, while MCs help homogenize GC spatial representations. |
format | Online Article Text |
id | pubmed-7486408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74864082020-09-25 Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus Kim, Soyoun Jung, Dajung Royer, Sébastien Nat Commun Article Place cells exhibit spatially selective firing fields that collectively map the continuum of positions in environments; how such activity pattern develops with experience is largely unknown. Here, we record putative granule cells (GCs) and mossy cells (MCs) from the dentate gyrus (DG) over 27 days as mice repetitively run through a sequence of objects fixed onto a treadmill belt. We observe a progressive transformation of GC spatial representations, from a sparse encoding of object locations and spatial patterns to increasingly more single, evenly dispersed place fields, while MCs show little transformation and preferentially encode object locations. A competitive learning model of the DG reproduces GC transformations via the progressive integration of landmark-vector cells and spatial inputs and requires MC-mediated feedforward inhibition to evenly distribute GC representations, suggesting that GCs slowly encode conjunctions of objects and spatial information via competitive learning, while MCs help homogenize GC spatial representations. Nature Publishing Group UK 2020-09-11 /pmc/articles/PMC7486408/ /pubmed/32917862 http://dx.doi.org/10.1038/s41467-020-18351-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kim, Soyoun Jung, Dajung Royer, Sébastien Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus |
title | Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus |
title_full | Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus |
title_fullStr | Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus |
title_full_unstemmed | Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus |
title_short | Place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus |
title_sort | place cell maps slowly develop via competitive learning and conjunctive coding in the dentate gyrus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486408/ https://www.ncbi.nlm.nih.gov/pubmed/32917862 http://dx.doi.org/10.1038/s41467-020-18351-6 |
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