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The effect of PEGylated iron oxide nanoparticles on sheep ovarian tissue: An ex-vivo nanosafety study
Today, nanotechnology plays an important role in our ever-continuous quest to improve the quality of human life. Because of their infinitesimal size, nanostructures can actively interact and alter cellular functions. Therefore, while the clinical benefits of nanotechnology may outweigh most of the a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486432/ https://www.ncbi.nlm.nih.gov/pubmed/32954036 http://dx.doi.org/10.1016/j.heliyon.2020.e04862 |
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author | Karimi, Sareh Tabatabaei, Seyed Nasrollah Gutleb, Arno C. Ghaffari Novin, Marefat Ebrahimzadeh-Bideskan, Alireza Shams Mofarahe, Zahra |
author_facet | Karimi, Sareh Tabatabaei, Seyed Nasrollah Gutleb, Arno C. Ghaffari Novin, Marefat Ebrahimzadeh-Bideskan, Alireza Shams Mofarahe, Zahra |
author_sort | Karimi, Sareh |
collection | PubMed |
description | Today, nanotechnology plays an important role in our ever-continuous quest to improve the quality of human life. Because of their infinitesimal size, nanostructures can actively interact and alter cellular functions. Therefore, while the clinical benefits of nanotechnology may outweigh most of the associated risks, assessment of the cytotoxicity of nanostructures in respect to cells and tissues early in product development processes is of great significance. To the best of our knowledge, no such assessment has been performed for nanomaterials on the ovarian cortex before. Herein, silica-coated, PEGylated silica-coated, and uncoated iron oxide nanoparticles (IONP) with core diameter of 11 nm (±4.2 nm) were synthesized. The oxidative stress in cultured ovarian tissue exposed to the various IONP was subsequently assessed. The results indicate that among the four groups, uncoated IONP induce the most oxidative stress on the ovarian cortex while tissues treated with PEGylated IONP exhibit no significant change in oxidative stress. |
format | Online Article Text |
id | pubmed-7486432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74864322020-09-17 The effect of PEGylated iron oxide nanoparticles on sheep ovarian tissue: An ex-vivo nanosafety study Karimi, Sareh Tabatabaei, Seyed Nasrollah Gutleb, Arno C. Ghaffari Novin, Marefat Ebrahimzadeh-Bideskan, Alireza Shams Mofarahe, Zahra Heliyon Research Article Today, nanotechnology plays an important role in our ever-continuous quest to improve the quality of human life. Because of their infinitesimal size, nanostructures can actively interact and alter cellular functions. Therefore, while the clinical benefits of nanotechnology may outweigh most of the associated risks, assessment of the cytotoxicity of nanostructures in respect to cells and tissues early in product development processes is of great significance. To the best of our knowledge, no such assessment has been performed for nanomaterials on the ovarian cortex before. Herein, silica-coated, PEGylated silica-coated, and uncoated iron oxide nanoparticles (IONP) with core diameter of 11 nm (±4.2 nm) were synthesized. The oxidative stress in cultured ovarian tissue exposed to the various IONP was subsequently assessed. The results indicate that among the four groups, uncoated IONP induce the most oxidative stress on the ovarian cortex while tissues treated with PEGylated IONP exhibit no significant change in oxidative stress. Elsevier 2020-09-06 /pmc/articles/PMC7486432/ /pubmed/32954036 http://dx.doi.org/10.1016/j.heliyon.2020.e04862 Text en © 2020 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Karimi, Sareh Tabatabaei, Seyed Nasrollah Gutleb, Arno C. Ghaffari Novin, Marefat Ebrahimzadeh-Bideskan, Alireza Shams Mofarahe, Zahra The effect of PEGylated iron oxide nanoparticles on sheep ovarian tissue: An ex-vivo nanosafety study |
title | The effect of PEGylated iron oxide nanoparticles on sheep ovarian tissue: An ex-vivo nanosafety study |
title_full | The effect of PEGylated iron oxide nanoparticles on sheep ovarian tissue: An ex-vivo nanosafety study |
title_fullStr | The effect of PEGylated iron oxide nanoparticles on sheep ovarian tissue: An ex-vivo nanosafety study |
title_full_unstemmed | The effect of PEGylated iron oxide nanoparticles on sheep ovarian tissue: An ex-vivo nanosafety study |
title_short | The effect of PEGylated iron oxide nanoparticles on sheep ovarian tissue: An ex-vivo nanosafety study |
title_sort | effect of pegylated iron oxide nanoparticles on sheep ovarian tissue: an ex-vivo nanosafety study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486432/ https://www.ncbi.nlm.nih.gov/pubmed/32954036 http://dx.doi.org/10.1016/j.heliyon.2020.e04862 |
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