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Genome of Tetraploid Fish Schizothorax o'connori Provides Insights into Early Re-diploidization and High-Altitude Adaptation

Whole-genome duplications (WGDs) of Schizothoracinae are believed to have played a significant role in speciation and environmental adaptation on the Qinghai-Tibet Plateau (QTP). Here, we present a genome for Schizothorax o'connori, a QTP endemic fish and showed the species as a young tetraploi...

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Detalles Bibliográficos
Autores principales: Xiao, Shijun, Mou, Zhenbo, Fan, Dingding, Zhou, He, Zou, Ming, Zou, Yu, Zhou, Chaowei, Yang, Ruibin, Liu, Jiaqi, Zhu, Shilin, Li, Yajuan, Liu, Yanchao, Liu, Fei, Wang, Wanliang, Zeng, Benhe, Li, Hong, Wang, Di, Liu, Haiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486454/
https://www.ncbi.nlm.nih.gov/pubmed/32905880
http://dx.doi.org/10.1016/j.isci.2020.101497
Descripción
Sumario:Whole-genome duplications (WGDs) of Schizothoracinae are believed to have played a significant role in speciation and environmental adaptation on the Qinghai-Tibet Plateau (QTP). Here, we present a genome for Schizothorax o'connori, a QTP endemic fish and showed the species as a young tetraploid with a recent WGD later than ∼1.23 mya. We exhibited that massive insertions between duplicated genomes caused by transposon bursts could induce mutagenesis in adjacent sequences and alter the expression of neighboring genes, representing an early re-diploidization process in a polyploid genome after WGD. Meanwhile, we found that many genes involved in DNA repair and folate transport/metabolism experienced natural selection and might contribute to the environmental adaptation of this species. Therefore, the S. o'connori genome could serve as a young tetraploid model for investigations of early re-diploidization in polyploid genomes and offers an invaluable genetic resource for environmental adaptation studies of the endemic fish of the QTP.