Cargando…

NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway

Transcription factor nuclear factor-erythroid 2-like 2 (NRF2) mainly regulates cellular antioxidant response, redox homeostasis and metabolic balance. Our previous study illustrated the translational significance of NRF2-mediated transcriptional repression, and the transcription of FOCAD gene might...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Pengfei, Wu, Di, Duan, Jinyue, Xiao, Hexin, Zhou, Yulai, Zhao, Lei, Feng, Yetong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486457/ https://www.ncbi.nlm.nih.gov/pubmed/32898818 http://dx.doi.org/10.1016/j.redox.2020.101702

Ejemplares similares

COX7A1 enhances the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via regulating mitochondrial metabolism
por: Feng, Yetong, et al.
Publicado: (2022)

CISD3 inhibition drives cystine-deprivation induced ferroptosis
por: Li, Yanchun, et al.
Publicado: (2021)

Discovery of FOCAD: An Important Gene in Liver Cirrhosis
por: Shao, Jinjin
Publicado: (2022)

Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer
por: Shin, Daiha, et al.
Publicado: (2020)

Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation–induced ferroptosis
por: Hayashima, Kazuki, et al.
Publicado: (2022)

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
por: Hayano, M, et al.
Publicado: (2016)

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development
por: Weren, Robbert DA, et al.
Publicado: (2015)

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
por: Shi, Zhennan, et al.
Publicado: (2021)

PRICKLE1 × FOCAD Interaction Revealed by Genome-Wide vQTL Analysis of Human Facial Traits
por: Liu, Dongjing, et al.
Publicado: (2021)

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis
por: Yu, Xinlei, et al.
Publicado: (2016)

Author Correction: Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
por: Shi, Zhennan, et al.
Publicado: (2023)

Ferroptosis contributes to isoflurane-induced neurotoxicity and learning and memory impairment
por: Liu, Pengfei, et al.
Publicado: (2021)

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
por: Dixon, Scott J, et al.
Publicado: (2014)

Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1
por: Cho, Il-Je, et al.
Publicado: (2021)

Fresh Medium or L-Cystine as an Effective Nrf2 Inducer for Cytoprotection in Cell Culture
por: Dai, Wujing, et al.
Publicado: (2023)

Cystine nephrolithiasis
por: Fattah, Hasan, et al.
Publicado: (2014)

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis
por: Liu, Pengfei, et al.
Publicado: (2020)

Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis
por: Huang, Yongzhou, et al.
Publicado: (2023)

Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells
por: Ensink, Elliot, et al.
Publicado: (2023)

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis
por: Ashraf, Azhaar, et al.
Publicado: (2020)

Glutamine deprivation induces ferroptosis in pancreatic cancer cells: Glutamine deprivation induces pancreatic cancer ferroptosis
por: Xiao, Zhiwen, et al.
Publicado: (2023)

Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway
por: Zhu, Jin-Feng, et al.
Publicado: (2023)

Targeting NRF2 Sensitizes Esophageal Adenocarcinoma Cells to Cisplatin through Induction of Ferroptosis and Apoptosis
por: Ballout, Farah, et al.
Publicado: (2022)

SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes
por: Tong, Qing, et al.
Publicado: (2023)

Enhanced renoprotective effect of IGF-1 modified human umbilical cord-derived mesenchymal stem cells on gentamicin-induced acute kidney injury
por: Liu, Pengfei, et al.
Publicado: (2016)

Cystinuria and Cystine Calculi
Publicado: (1930)

A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT(KO) Pancreatic Ductal Adenocarcinoma Cells
por: Meira, Willian, et al.
Publicado: (2021)

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
por: Koppula, Pranavi, et al.
Publicado: (2020)

NRF2, a Superstar of Ferroptosis
por: Yan, Ruihan, et al.
Publicado: (2023)

Identification of ferroptosis-related genes and predicted overall survival in patients with burns
por: Zhao, Mingjian, et al.
Publicado: (2023)

FAK-Copy-Gain Is a Predictive Marker for Sensitivity to FAK Inhibition in Breast Cancer
por: Kim, Young-Ho, et al.
Publicado: (2019)

Accurate 24-h urine cystine quantification for patients on cystine-binding thiol drugs
por: Mikel, Charles C., et al.
Publicado: (2022)

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
por: Muir, Alexander, et al.
Publicado: (2017)

Extracellular Concentration of L-Cystine Determines the Sensitivity to System x(c)(-) Inhibitors
por: Abdullah, Md, et al.
Publicado: (2022)

Camptothecin Sensitizes Hepatocellular Carcinoma Cells to Sorafenib- Induced Ferroptosis Via Suppression of Nrf2
por: Elkateb, Ahmed S., et al.
Publicado: (2023)

Neuroprotection of NRF2 against Ferroptosis after Traumatic Brain Injury in Mice
por: Cheng, Hao, et al.
Publicado: (2023)

Administration of BMSCs with Muscone in Rats with Gentamicin-Induced AKI Improves Their Therapeutic Efficacy
por: Liu, Pengfei, et al.
Publicado: (2014)

Hypermethylation of the Nrf2 Promoter Induces Ferroptosis by Inhibiting the Nrf2-GPX4 Axis in COPD
por: Zhang, Zixiao, et al.
Publicado: (2021)

Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS–mitochondrial fission–mitophagy axis
por: Liu, Ming, et al.
Publicado: (2021)

S-3′-hydroxy-7′, 2′, 4′-trimethoxyisoxane, a novel ferroptosis inducer, promotes NSCLC cell death through inhibiting Nrf2/HO-1 signaling pathway
por: Chen, Jing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3cg6q56fqmpr4im5crft64hlvs