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A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Endoplasmic reticulum stress (ERS) is generally activated in HCC and is important for the sensitivity of HCC to anticancer drugs. ERS-dependent autophagy is a crucial mechanism affecting the sensitivity of HCC to...

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Autores principales: Cui, Jie, Liu, Jiatao, Fan, Lulu, Zhu, Yue, Zhou, Bei, Wang, Yu, Hua, Wei, Wei, Wei, Sun, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486481/
https://www.ncbi.nlm.nih.gov/pubmed/32898766
http://dx.doi.org/10.1016/j.tranon.2020.100851
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author Cui, Jie
Liu, Jiatao
Fan, Lulu
Zhu, Yue
Zhou, Bei
Wang, Yu
Hua, Wei
Wei, Wei
Sun, Guoping
author_facet Cui, Jie
Liu, Jiatao
Fan, Lulu
Zhu, Yue
Zhou, Bei
Wang, Yu
Hua, Wei
Wei, Wei
Sun, Guoping
author_sort Cui, Jie
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Endoplasmic reticulum stress (ERS) is generally activated in HCC and is important for the sensitivity of HCC to anticancer drugs. ERS-dependent autophagy is a crucial mechanism affecting the sensitivity of HCC to anticancer drugs, but the mechanism by which ERS regulates autophagy is not well understood. Zinc finger protein 263 (ZNF263) is a transcription factor member of the zinc finger family. However, its functional role in HCC remains to be studied. In the current study, we investigated the role of ZNF263 in regulating ERS-induced chemoresistance in HCC and its possible mechanism. We found that ZNF263 was the most significant ERS-specific super-enhancer bounding transcriptional factor and was up-regulated in HCC patients and cell lines. Further, ZNF263 expression correlated with ERS, clinical stage and shorter survival in HCC patients. ZNF263 knockdown by RNA interference results in decreased proliferation, apoptosis resistance, and chemoresistance. Further study showed that ZNF263 increased chemoresistance by activating ERS-related autophagy. In conclusion, our study highlights ZNF263 as a functional ERS-related tumor activator and indicates it as a potential target for HCC therapy.
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spelling pubmed-74864812020-09-18 A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy Cui, Jie Liu, Jiatao Fan, Lulu Zhu, Yue Zhou, Bei Wang, Yu Hua, Wei Wei, Wei Sun, Guoping Transl Oncol Original article Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Endoplasmic reticulum stress (ERS) is generally activated in HCC and is important for the sensitivity of HCC to anticancer drugs. ERS-dependent autophagy is a crucial mechanism affecting the sensitivity of HCC to anticancer drugs, but the mechanism by which ERS regulates autophagy is not well understood. Zinc finger protein 263 (ZNF263) is a transcription factor member of the zinc finger family. However, its functional role in HCC remains to be studied. In the current study, we investigated the role of ZNF263 in regulating ERS-induced chemoresistance in HCC and its possible mechanism. We found that ZNF263 was the most significant ERS-specific super-enhancer bounding transcriptional factor and was up-regulated in HCC patients and cell lines. Further, ZNF263 expression correlated with ERS, clinical stage and shorter survival in HCC patients. ZNF263 knockdown by RNA interference results in decreased proliferation, apoptosis resistance, and chemoresistance. Further study showed that ZNF263 increased chemoresistance by activating ERS-related autophagy. In conclusion, our study highlights ZNF263 as a functional ERS-related tumor activator and indicates it as a potential target for HCC therapy. Neoplasia Press 2020-09-06 /pmc/articles/PMC7486481/ /pubmed/32898766 http://dx.doi.org/10.1016/j.tranon.2020.100851 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original article
Cui, Jie
Liu, Jiatao
Fan, Lulu
Zhu, Yue
Zhou, Bei
Wang, Yu
Hua, Wei
Wei, Wei
Sun, Guoping
A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy
title A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy
title_full A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy
title_fullStr A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy
title_full_unstemmed A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy
title_short A zinc finger family protein, ZNF263, promotes hepatocellular carcinoma resistance to apoptosis via activation of ER stress-dependent autophagy
title_sort zinc finger family protein, znf263, promotes hepatocellular carcinoma resistance to apoptosis via activation of er stress-dependent autophagy
topic Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486481/
https://www.ncbi.nlm.nih.gov/pubmed/32898766
http://dx.doi.org/10.1016/j.tranon.2020.100851
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