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Crosstalk between RNA m(6)A Modification and Non-coding RNA Contributes to Cancer Growth and Progression

N6-methyladenosine (m(6)A) is the most common RNA modification and has an important role in normal development and tumorigenesis. The abnormal expression of m(6)A regulators can lead to an imbalance in m(6)A levels in cancer cells, leading to the dysregulated expression of oncogenes and tumor suppre...

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Autores principales: Dai, Fengsheng, Wu, Yongyan, Lu, Yan, An, Changming, Zheng, Xiwang, Dai, Li, Guo, Yujia, Zhang, Linshi, Li, Huizheng, Xu, Wei, Gao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486578/
https://www.ncbi.nlm.nih.gov/pubmed/32911345
http://dx.doi.org/10.1016/j.omtn.2020.08.004
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author Dai, Fengsheng
Wu, Yongyan
Lu, Yan
An, Changming
Zheng, Xiwang
Dai, Li
Guo, Yujia
Zhang, Linshi
Li, Huizheng
Xu, Wei
Gao, Wei
author_facet Dai, Fengsheng
Wu, Yongyan
Lu, Yan
An, Changming
Zheng, Xiwang
Dai, Li
Guo, Yujia
Zhang, Linshi
Li, Huizheng
Xu, Wei
Gao, Wei
author_sort Dai, Fengsheng
collection PubMed
description N6-methyladenosine (m(6)A) is the most common RNA modification and has an important role in normal development and tumorigenesis. The abnormal expression of m(6)A regulators can lead to an imbalance in m(6)A levels in cancer cells, leading to the dysregulated expression of oncogenes and tumor suppressor genes that may contribute to cancer development, patient response to chemoradiotherapy, and clinical prognosis. Recent studies demonstrate that non-coding RNAs are involved in epigenetic modification of both DNA and RNA in tumor cells, and may also affect the development and progression of cancer by targeting m(6)A regulators. In this review, we describe the functional crosstalk between m(6)A and non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, and illustrate their roles in tumor regulation. Finally, we discuss the significance of non-coding RNA and m(6)A modification in the diagnosis, treatment, and prognosis of cancer patients, as well as potential future research directions.
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spelling pubmed-74865782020-09-28 Crosstalk between RNA m(6)A Modification and Non-coding RNA Contributes to Cancer Growth and Progression Dai, Fengsheng Wu, Yongyan Lu, Yan An, Changming Zheng, Xiwang Dai, Li Guo, Yujia Zhang, Linshi Li, Huizheng Xu, Wei Gao, Wei Mol Ther Nucleic Acids Review N6-methyladenosine (m(6)A) is the most common RNA modification and has an important role in normal development and tumorigenesis. The abnormal expression of m(6)A regulators can lead to an imbalance in m(6)A levels in cancer cells, leading to the dysregulated expression of oncogenes and tumor suppressor genes that may contribute to cancer development, patient response to chemoradiotherapy, and clinical prognosis. Recent studies demonstrate that non-coding RNAs are involved in epigenetic modification of both DNA and RNA in tumor cells, and may also affect the development and progression of cancer by targeting m(6)A regulators. In this review, we describe the functional crosstalk between m(6)A and non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, and illustrate their roles in tumor regulation. Finally, we discuss the significance of non-coding RNA and m(6)A modification in the diagnosis, treatment, and prognosis of cancer patients, as well as potential future research directions. American Society of Gene & Cell Therapy 2020-08-08 /pmc/articles/PMC7486578/ /pubmed/32911345 http://dx.doi.org/10.1016/j.omtn.2020.08.004 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dai, Fengsheng
Wu, Yongyan
Lu, Yan
An, Changming
Zheng, Xiwang
Dai, Li
Guo, Yujia
Zhang, Linshi
Li, Huizheng
Xu, Wei
Gao, Wei
Crosstalk between RNA m(6)A Modification and Non-coding RNA Contributes to Cancer Growth and Progression
title Crosstalk between RNA m(6)A Modification and Non-coding RNA Contributes to Cancer Growth and Progression
title_full Crosstalk between RNA m(6)A Modification and Non-coding RNA Contributes to Cancer Growth and Progression
title_fullStr Crosstalk between RNA m(6)A Modification and Non-coding RNA Contributes to Cancer Growth and Progression
title_full_unstemmed Crosstalk between RNA m(6)A Modification and Non-coding RNA Contributes to Cancer Growth and Progression
title_short Crosstalk between RNA m(6)A Modification and Non-coding RNA Contributes to Cancer Growth and Progression
title_sort crosstalk between rna m(6)a modification and non-coding rna contributes to cancer growth and progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486578/
https://www.ncbi.nlm.nih.gov/pubmed/32911345
http://dx.doi.org/10.1016/j.omtn.2020.08.004
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