Prevention and treatment of SHIVAD8 infection in rhesus macaques by a potent d-peptide HIV entry inhibitor

Cholesterol-PIE12-trimer (CPT31) is a potent d-peptide HIV entry inhibitor that targets the highly conserved gp41 N-peptide pocket region. CPT31 exhibited strong inhibitory breadth against diverse panels of primary virus isolates. In a simian-HIV chimeric virus AD8 (SHIVAD8) macaque model, CPT31 pre...

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Detalles Bibliográficos
Autores principales: Nishimura, Yoshiaki, Francis, J. Nicholas, Donau, Olivia K., Jesteadt, Eric, Sadjadpour, Reza, Smith, Amanda R., Seaman, Michael S., Welch, Brett D., Martin, Malcolm A., Kay, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486783/
https://www.ncbi.nlm.nih.gov/pubmed/32820072
http://dx.doi.org/10.1073/pnas.2009700117

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