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Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?

PURPOSE: SARS-CoV-2 (COVID-19) has infected more than 7 million people worldwide in the short time since it emerged in Wuhan, China in December 2019. The aim of this study was to investigate the relationship between serum interleukin 6 (IL-6) and surfactant protein D (SP-D) levels and the clinical c...

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Autores principales: Kerget, Buğra, Kerget, Ferhan, Koçak, Abdullah Osman, Kızıltunç, Ahmet, Araz, Ömer, Uçar, Elif Yılmazel, Akgün, Metin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486805/
https://www.ncbi.nlm.nih.gov/pubmed/32918573
http://dx.doi.org/10.1007/s00408-020-00393-8
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author Kerget, Buğra
Kerget, Ferhan
Koçak, Abdullah Osman
Kızıltunç, Ahmet
Araz, Ömer
Uçar, Elif Yılmazel
Akgün, Metin
author_facet Kerget, Buğra
Kerget, Ferhan
Koçak, Abdullah Osman
Kızıltunç, Ahmet
Araz, Ömer
Uçar, Elif Yılmazel
Akgün, Metin
author_sort Kerget, Buğra
collection PubMed
description PURPOSE: SARS-CoV-2 (COVID-19) has infected more than 7 million people worldwide in the short time since it emerged in Wuhan, China in December 2019. The aim of this study was to investigate the relationship between serum interleukin 6 (IL-6) and surfactant protein D (SP-D) levels and the clinical course and prognosis of COVID-19. MATERIALS AND METHODS: The study included a total of 108 individuals: 88 patients who were diagnosed with COVID-19 by real-time PCR of nasopharyngeal swab samples and admitted to the Atatürk University Pulmonary Diseases and the Erzurum City Hospital Infectious Diseases department between March 24 and April 15, and 20 asymptomatic healthcare workers who had negative real-time PCR results during routine COVID-19 screening in our hospital. RESULTS: Patients who developed macrophage activation syndrome had significantly higher IL-6 and SP-D levels at the time of admission and on day 5 of treatment compared to the other patients (IL-6: p = 0.001 for both; SP-D: p = 0.02, p = 0.04). Patients who developed acute respiratory distress syndrome had significantly higher IL-6 and SP-D levels at both time points compared to those who did not (p = 0.001 for all). Both parameters at the time of admission were also significantly higher among nonsurvivors compared to survivors (IL-6: p = 0.001, SP-D: p = 0.03). CONCLUSION: In addition to IL-6, which has an important role in predicting course and planning treatment in COVID-19, SP-D may be a novel pneumoprotein that can be used in the clinical course, follow-up, and possibly in future treatments. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00408-020-00393-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-74868052020-09-14 Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19? Kerget, Buğra Kerget, Ferhan Koçak, Abdullah Osman Kızıltunç, Ahmet Araz, Ömer Uçar, Elif Yılmazel Akgün, Metin Lung COVID-19 PULMONARY DISEASE and BIOMARKERS PURPOSE: SARS-CoV-2 (COVID-19) has infected more than 7 million people worldwide in the short time since it emerged in Wuhan, China in December 2019. The aim of this study was to investigate the relationship between serum interleukin 6 (IL-6) and surfactant protein D (SP-D) levels and the clinical course and prognosis of COVID-19. MATERIALS AND METHODS: The study included a total of 108 individuals: 88 patients who were diagnosed with COVID-19 by real-time PCR of nasopharyngeal swab samples and admitted to the Atatürk University Pulmonary Diseases and the Erzurum City Hospital Infectious Diseases department between March 24 and April 15, and 20 asymptomatic healthcare workers who had negative real-time PCR results during routine COVID-19 screening in our hospital. RESULTS: Patients who developed macrophage activation syndrome had significantly higher IL-6 and SP-D levels at the time of admission and on day 5 of treatment compared to the other patients (IL-6: p = 0.001 for both; SP-D: p = 0.02, p = 0.04). Patients who developed acute respiratory distress syndrome had significantly higher IL-6 and SP-D levels at both time points compared to those who did not (p = 0.001 for all). Both parameters at the time of admission were also significantly higher among nonsurvivors compared to survivors (IL-6: p = 0.001, SP-D: p = 0.03). CONCLUSION: In addition to IL-6, which has an important role in predicting course and planning treatment in COVID-19, SP-D may be a novel pneumoprotein that can be used in the clinical course, follow-up, and possibly in future treatments. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00408-020-00393-8) contains supplementary material, which is available to authorized users. Springer US 2020-09-12 2020 /pmc/articles/PMC7486805/ /pubmed/32918573 http://dx.doi.org/10.1007/s00408-020-00393-8 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle COVID-19 PULMONARY DISEASE and BIOMARKERS
Kerget, Buğra
Kerget, Ferhan
Koçak, Abdullah Osman
Kızıltunç, Ahmet
Araz, Ömer
Uçar, Elif Yılmazel
Akgün, Metin
Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?
title Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?
title_full Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?
title_fullStr Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?
title_full_unstemmed Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?
title_short Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?
title_sort are serum interleukin 6 and surfactant protein d levels associated with the clinical course of covid-19?
topic COVID-19 PULMONARY DISEASE and BIOMARKERS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486805/
https://www.ncbi.nlm.nih.gov/pubmed/32918573
http://dx.doi.org/10.1007/s00408-020-00393-8
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