Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019

Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cy...

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Autores principales: Patel, Maulin, Dominguez, Eduardo, Sacher, Daniel, Desai, Parag, Chandar, Ashwin, Bromberg, Michael, Caricchio, Roberto, Criner, Gerard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Chest Physicians. Published by Elsevier Inc. 2021
Materias:
Novel Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486855/
https://www.ncbi.nlm.nih.gov/pubmed/32931823
http://dx.doi.org/10.1016/j.chest.2020.09.077
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author Patel, Maulin
Dominguez, Eduardo
Sacher, Daniel
Desai, Parag
Chandar, Ashwin
Bromberg, Michael
Caricchio, Roberto
Criner, Gerard J.
author_facet Patel, Maulin
Dominguez, Eduardo
Sacher, Daniel
Desai, Parag
Chandar, Ashwin
Bromberg, Michael
Caricchio, Roberto
Criner, Gerard J.
author_sort Patel, Maulin
collection PubMed
description Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of etoposide in COVID-19.
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spelling pubmed-74868552020-09-14 Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019 Patel, Maulin Dominguez, Eduardo Sacher, Daniel Desai, Parag Chandar, Ashwin Bromberg, Michael Caricchio, Roberto Criner, Gerard J. Chest Novel Reports Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of etoposide in COVID-19. American College of Chest Physicians. Published by Elsevier Inc. 2021-01 2020-09-12 /pmc/articles/PMC7486855/ /pubmed/32931823 http://dx.doi.org/10.1016/j.chest.2020.09.077 Text en © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Novel Reports
Patel, Maulin
Dominguez, Eduardo
Sacher, Daniel
Desai, Parag
Chandar, Ashwin
Bromberg, Michael
Caricchio, Roberto
Criner, Gerard J.
Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019
title Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019
title_full Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019
title_fullStr Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019
title_full_unstemmed Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019
title_short Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019
title_sort etoposide as salvage therapy for cytokine storm due to coronavirus disease 2019
topic Novel Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486855/
https://www.ncbi.nlm.nih.gov/pubmed/32931823
http://dx.doi.org/10.1016/j.chest.2020.09.077
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