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Preclinical optimization of an enterotoxigenic Escherichia coli adjuvanted subunit vaccine using response surface design of experiments

Enterotoxigenic E. coli (ETEC) is a leading cause of moderate-to-severe diarrhoea. ETEC colonizes the intestine through fimbrial tip adhesin colonization factors and produces heat-stable and/or heat-labile (LT) toxins, stimulating fluid and electrolyte release leading to watery diarrhoea. We reporte...

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Detalles Bibliográficos
Autores principales:	Poncet, David, Hessler, Catherine, Liang, Hong, Gautheron, Sylviane, Sergent, Michelle, Rintala, Nicholas D., Seydoux, Emilie, Huang, Po-Wei D., Argilla, David, Ruiz, Sophie, Heinrichs, Jon, Maciel, Milton, Orr, Mark T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486917/ https://www.ncbi.nlm.nih.gov/pubmed/32983577 http://dx.doi.org/10.1038/s41541-020-00228-w

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