Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease

Human ubiquitin carboxyl-terminal hydrolase-2 (USP2) inhibitors, such as thiopurine analogs, have been reported to inhibit SARS-CoV papain-like proteases (PLpro). The PLpro have significant functional implications in the innate immune response during SARS-CoV-2 infection and considered an important...

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Detalles Bibliográficos
Autores principales: Mirza, Muhammad Usman, Ahmad, Sarfraz, Abdullah, Iskandar, Froeyen, Matheus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487165/
https://www.ncbi.nlm.nih.gov/pubmed/32979815
http://dx.doi.org/10.1016/j.compbiolchem.2020.107376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487165/
https://www.ncbi.nlm.nih.gov/pubmed/32979815
http://dx.doi.org/10.1016/j.compbiolchem.2020.107376

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