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Single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread

SUMMARY: Well-differentiated thyroid cancer (WDTC), including papillary, follicular, and Hurthle-cell types, is characterized by a slow course and usually remain localized to the thyroid. However, a minority of these cases develop distant metastases with the most common sites being lungs, bones, and...

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Autores principales: Ostrovsky, Viviana, Bar-Zakai, Barak, Miller, Rafael, Schiller, Tal, Kirzhner, Alena, Knobler, Hilla, Zornitzki, Taiba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487177/
https://www.ncbi.nlm.nih.gov/pubmed/32820131
http://dx.doi.org/10.1530/EDM-20-0074
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author Ostrovsky, Viviana
Bar-Zakai, Barak
Miller, Rafael
Schiller, Tal
Kirzhner, Alena
Knobler, Hilla
Zornitzki, Taiba
author_facet Ostrovsky, Viviana
Bar-Zakai, Barak
Miller, Rafael
Schiller, Tal
Kirzhner, Alena
Knobler, Hilla
Zornitzki, Taiba
author_sort Ostrovsky, Viviana
collection PubMed
description SUMMARY: Well-differentiated thyroid cancer (WDTC), including papillary, follicular, and Hurthle-cell types, is characterized by a slow course and usually remain localized to the thyroid. However, a minority of these cases develop distant metastases with the most common sites being lungs, bones, and lymph nodes. Liver metastases of WDTC are rare and are usually found along with other distant metastases sites and in a multiple or diffuse pattern of spread. The recognition of distant metastasis in WDTC has a significant impact on the treatment and prognosis. However, because of their low incidence and awareness, distant metastases are often diagnosed late. Herein, we describe a case of a 71 years old woman who during routine surveillance of a follicular variant of papillary thyroid cancer (FV-PTC), 5 years after being treated for her primary thyroid tumor, was found to have a single liver metastasis and underwent liver segmental resection. This case highlights the importance of maintaining vigilant surveillance of patients with WDTC, and illustrates the possibility of unique metastasis at unexpected sites. Further studies are needed to understand the organ tropism of some WDTC leading to distant metastases development and to better prediction of an aggressive course. LEARNING POINTS: WDTC patients with distant metastases have a poor prognosis with a 10-year survival of about 50%. The most common sites of distant metastases are lung, bone and lymph nodes. Liver metastases are rare in WDTC, are usually multiple or diffuse and are found along with other distant metastases sites. Single liver metastasis of WDTC is an unexpected pattern of spread, and very few cases are reported in the literature. Rare sites of distant metastases in WDTC can manifest many years after the primary tumor, stressing the importance of maintaining vigilant surveillance. More studies are needed to predict which WDTC tumors may develop a more aggressive course, allowing clinicians to individualize patient management.
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spelling pubmed-74871772020-09-16 Single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread Ostrovsky, Viviana Bar-Zakai, Barak Miller, Rafael Schiller, Tal Kirzhner, Alena Knobler, Hilla Zornitzki, Taiba Endocrinol Diabetes Metab Case Rep Unique/Unexpected Symptoms or Presentations of a Disease SUMMARY: Well-differentiated thyroid cancer (WDTC), including papillary, follicular, and Hurthle-cell types, is characterized by a slow course and usually remain localized to the thyroid. However, a minority of these cases develop distant metastases with the most common sites being lungs, bones, and lymph nodes. Liver metastases of WDTC are rare and are usually found along with other distant metastases sites and in a multiple or diffuse pattern of spread. The recognition of distant metastasis in WDTC has a significant impact on the treatment and prognosis. However, because of their low incidence and awareness, distant metastases are often diagnosed late. Herein, we describe a case of a 71 years old woman who during routine surveillance of a follicular variant of papillary thyroid cancer (FV-PTC), 5 years after being treated for her primary thyroid tumor, was found to have a single liver metastasis and underwent liver segmental resection. This case highlights the importance of maintaining vigilant surveillance of patients with WDTC, and illustrates the possibility of unique metastasis at unexpected sites. Further studies are needed to understand the organ tropism of some WDTC leading to distant metastases development and to better prediction of an aggressive course. LEARNING POINTS: WDTC patients with distant metastases have a poor prognosis with a 10-year survival of about 50%. The most common sites of distant metastases are lung, bone and lymph nodes. Liver metastases are rare in WDTC, are usually multiple or diffuse and are found along with other distant metastases sites. Single liver metastasis of WDTC is an unexpected pattern of spread, and very few cases are reported in the literature. Rare sites of distant metastases in WDTC can manifest many years after the primary tumor, stressing the importance of maintaining vigilant surveillance. More studies are needed to predict which WDTC tumors may develop a more aggressive course, allowing clinicians to individualize patient management. Bioscientifica Ltd 2020-08-20 /pmc/articles/PMC7487177/ /pubmed/32820131 http://dx.doi.org/10.1530/EDM-20-0074 Text en © 2020 The authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (http://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Unique/Unexpected Symptoms or Presentations of a Disease
Ostrovsky, Viviana
Bar-Zakai, Barak
Miller, Rafael
Schiller, Tal
Kirzhner, Alena
Knobler, Hilla
Zornitzki, Taiba
Single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread
title Single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread
title_full Single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread
title_fullStr Single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread
title_full_unstemmed Single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread
title_short Single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread
title_sort single liver metastasis of a follicular variant of papillary thyroid carcinoma: a rare pattern of organ spread
topic Unique/Unexpected Symptoms or Presentations of a Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487177/
https://www.ncbi.nlm.nih.gov/pubmed/32820131
http://dx.doi.org/10.1530/EDM-20-0074
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