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Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine
Plasmalogens are a special class of polar glycerolipids containing a vinyl-ether bond and an ester bond at sn-1 and sn-2 positions of the glycerol backbone, respectively. In animals, impaired biosynthesis and regulation of plasmalogens may lead to certain neurological and metabolic diseases. Plasmal...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487321/ https://www.ncbi.nlm.nih.gov/pubmed/32984309 http://dx.doi.org/10.3389/fcell.2020.00765 |
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author | Zhou, Yulong Yu, Ning Zhao, Jie Xie, Zhenming Yang, Zhaonan Tian, Bing |
author_facet | Zhou, Yulong Yu, Ning Zhao, Jie Xie, Zhenming Yang, Zhaonan Tian, Bing |
author_sort | Zhou, Yulong |
collection | PubMed |
description | Plasmalogens are a special class of polar glycerolipids containing a vinyl-ether bond and an ester bond at sn-1 and sn-2 positions of the glycerol backbone, respectively. In animals, impaired biosynthesis and regulation of plasmalogens may lead to certain neurological and metabolic diseases. Plasmalogens deficiency was proposed to be strongly associated with neurodegenerative and metabolic diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), and appropriate supplement of plasmalogens could help to prevent and possibly provide therapy of these diseases. Plasmalogens evolved first in anaerobic bacteria with an anaerobic biosynthetic pathway. Later, an oxygen-dependent biosynthesis of plasmalogens appeared in animal cells. This review summarizes and updates current knowledge of anaerobic and aerobic pathways of plasmalogens biosynthesis, including the enzymes involved, steps and aspects of the regulation of these processes. Strategies for increasing the expression of plasmalogen synthetic genes using synthetic biology techniques under specific conditions are discussed. Deep understanding of plasmalogens biosynthesis will provide the bases for the use of plasmalogens and their precursors as potential therapeutic regimens for age-related degenerative and metabolic diseases. |
format | Online Article Text |
id | pubmed-7487321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74873212020-09-25 Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine Zhou, Yulong Yu, Ning Zhao, Jie Xie, Zhenming Yang, Zhaonan Tian, Bing Front Cell Dev Biol Cell and Developmental Biology Plasmalogens are a special class of polar glycerolipids containing a vinyl-ether bond and an ester bond at sn-1 and sn-2 positions of the glycerol backbone, respectively. In animals, impaired biosynthesis and regulation of plasmalogens may lead to certain neurological and metabolic diseases. Plasmalogens deficiency was proposed to be strongly associated with neurodegenerative and metabolic diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), and appropriate supplement of plasmalogens could help to prevent and possibly provide therapy of these diseases. Plasmalogens evolved first in anaerobic bacteria with an anaerobic biosynthetic pathway. Later, an oxygen-dependent biosynthesis of plasmalogens appeared in animal cells. This review summarizes and updates current knowledge of anaerobic and aerobic pathways of plasmalogens biosynthesis, including the enzymes involved, steps and aspects of the regulation of these processes. Strategies for increasing the expression of plasmalogen synthetic genes using synthetic biology techniques under specific conditions are discussed. Deep understanding of plasmalogens biosynthesis will provide the bases for the use of plasmalogens and their precursors as potential therapeutic regimens for age-related degenerative and metabolic diseases. Frontiers Media S.A. 2020-08-31 /pmc/articles/PMC7487321/ /pubmed/32984309 http://dx.doi.org/10.3389/fcell.2020.00765 Text en Copyright © 2020 Zhou, Yu, Zhao, Xie, Yang and Tian. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhou, Yulong Yu, Ning Zhao, Jie Xie, Zhenming Yang, Zhaonan Tian, Bing Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine |
title | Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine |
title_full | Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine |
title_fullStr | Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine |
title_full_unstemmed | Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine |
title_short | Advances in the Biosynthetic Pathways and Application Potential of Plasmalogens in Medicine |
title_sort | advances in the biosynthetic pathways and application potential of plasmalogens in medicine |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487321/ https://www.ncbi.nlm.nih.gov/pubmed/32984309 http://dx.doi.org/10.3389/fcell.2020.00765 |
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