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Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia

Chest computed tomography (CT) is the gold standard for detecting structural abnormalities in patients with primary ciliary dyskinesia (PCD) such as bronchiectasis, bronchial wall thickening and mucus plugging. There are no studies on quantitative assessment of airway and artery abnormalities in chi...

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Autores principales: Ferraro, Valentina, Andrinopoulou, Eleni-Rosalina, Sijbring, Anna Marthe Margaretha, Haarman, Eric G., Tiddens, Harm A.W.M., Pijnenburg, Marielle W.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487358/
https://www.ncbi.nlm.nih.gov/pubmed/32964004
http://dx.doi.org/10.1183/23120541.00210-2019
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author Ferraro, Valentina
Andrinopoulou, Eleni-Rosalina
Sijbring, Anna Marthe Margaretha
Haarman, Eric G.
Tiddens, Harm A.W.M.
Pijnenburg, Marielle W.H.
author_facet Ferraro, Valentina
Andrinopoulou, Eleni-Rosalina
Sijbring, Anna Marthe Margaretha
Haarman, Eric G.
Tiddens, Harm A.W.M.
Pijnenburg, Marielle W.H.
author_sort Ferraro, Valentina
collection PubMed
description Chest computed tomography (CT) is the gold standard for detecting structural abnormalities in patients with primary ciliary dyskinesia (PCD) such as bronchiectasis, bronchial wall thickening and mucus plugging. There are no studies on quantitative assessment of airway and artery abnormalities in children with PCD. The objectives of the present study were to quantify airway and artery dimensions on chest CT in a cohort of children with PCD and compare these with control children to analyse the influence of covariates on airway and artery dimensions. Chest CTs of 13 children with PCD (14 CT scans) and 12 control children were collected retrospectively. The bronchial tree was segmented semi-automatically and reconstructed in a three-dimensional view. All visible airway–artery (AA) pairs were measured perpendicular to the airway centre line, annotating per branch inner and outer airway and adjacent artery diameter and computing inner airway diameter/artery ratio (AinA ratio), outer airway diameter/artery ratio (AoutA ratio), wall thickness (WT), WT/outer airway diameter ratio (Awt ratio) and WT/artery ratio. In the children with PCD (38.5% male, mean age 13.5 years, range 9.8–15.3) 1526 AA pairs were measured versus 1516 in controls (58.3% male, mean age 13.5 years, range 8–14.8). AinA ratio and AoutA ratio were significantly higher in children with PCD than in control children (both p<0.001). Awt ratio was significantly higher in control children than in children with PCD (p<0.001). Our study showed that in children with PCD airways are more dilated than in controls and do not show airway wall thickening.
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spelling pubmed-74873582020-09-21 Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia Ferraro, Valentina Andrinopoulou, Eleni-Rosalina Sijbring, Anna Marthe Margaretha Haarman, Eric G. Tiddens, Harm A.W.M. Pijnenburg, Marielle W.H. ERJ Open Res Original Articles Chest computed tomography (CT) is the gold standard for detecting structural abnormalities in patients with primary ciliary dyskinesia (PCD) such as bronchiectasis, bronchial wall thickening and mucus plugging. There are no studies on quantitative assessment of airway and artery abnormalities in children with PCD. The objectives of the present study were to quantify airway and artery dimensions on chest CT in a cohort of children with PCD and compare these with control children to analyse the influence of covariates on airway and artery dimensions. Chest CTs of 13 children with PCD (14 CT scans) and 12 control children were collected retrospectively. The bronchial tree was segmented semi-automatically and reconstructed in a three-dimensional view. All visible airway–artery (AA) pairs were measured perpendicular to the airway centre line, annotating per branch inner and outer airway and adjacent artery diameter and computing inner airway diameter/artery ratio (AinA ratio), outer airway diameter/artery ratio (AoutA ratio), wall thickness (WT), WT/outer airway diameter ratio (Awt ratio) and WT/artery ratio. In the children with PCD (38.5% male, mean age 13.5 years, range 9.8–15.3) 1526 AA pairs were measured versus 1516 in controls (58.3% male, mean age 13.5 years, range 8–14.8). AinA ratio and AoutA ratio were significantly higher in children with PCD than in control children (both p<0.001). Awt ratio was significantly higher in control children than in children with PCD (p<0.001). Our study showed that in children with PCD airways are more dilated than in controls and do not show airway wall thickening. European Respiratory Society 2020-09-14 /pmc/articles/PMC7487358/ /pubmed/32964004 http://dx.doi.org/10.1183/23120541.00210-2019 Text en Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Original Articles
Ferraro, Valentina
Andrinopoulou, Eleni-Rosalina
Sijbring, Anna Marthe Margaretha
Haarman, Eric G.
Tiddens, Harm A.W.M.
Pijnenburg, Marielle W.H.
Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia
title Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia
title_full Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia
title_fullStr Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia
title_full_unstemmed Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia
title_short Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia
title_sort airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487358/
https://www.ncbi.nlm.nih.gov/pubmed/32964004
http://dx.doi.org/10.1183/23120541.00210-2019
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