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Thromboembolic disease in COVID-19 patients: A brief narrative review

Corona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease and is seen in a multitude of organ systems ranging from cutaneous thrombosis to pulmonary emb...

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Autores principales: Mondal, Samhati, Quintili, Ashley L., Karamchandani, Kunal, Bose, Somnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487447/
https://www.ncbi.nlm.nih.gov/pubmed/32939266
http://dx.doi.org/10.1186/s40560-020-00483-y
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author Mondal, Samhati
Quintili, Ashley L.
Karamchandani, Kunal
Bose, Somnath
author_facet Mondal, Samhati
Quintili, Ashley L.
Karamchandani, Kunal
Bose, Somnath
author_sort Mondal, Samhati
collection PubMed
description Corona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease and is seen in a multitude of organ systems ranging from cutaneous thrombosis to pulmonary embolism, stroke or coronary thrombosis sometimes with catastrophic outcomes. Evidence points towards a key role of thromboembolism, hypercoagulability and over production of proinflammatory cytokines mimicking a “cytokine storm” which leads to multiorgan failure. This brief narrative review highlights the pathophysiology and risk factors of thromboembolic disease and provides a framework for management of anticoagulation based on the current evidence.
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spelling pubmed-74874472020-09-14 Thromboembolic disease in COVID-19 patients: A brief narrative review Mondal, Samhati Quintili, Ashley L. Karamchandani, Kunal Bose, Somnath J Intensive Care Review Corona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease and is seen in a multitude of organ systems ranging from cutaneous thrombosis to pulmonary embolism, stroke or coronary thrombosis sometimes with catastrophic outcomes. Evidence points towards a key role of thromboembolism, hypercoagulability and over production of proinflammatory cytokines mimicking a “cytokine storm” which leads to multiorgan failure. This brief narrative review highlights the pathophysiology and risk factors of thromboembolic disease and provides a framework for management of anticoagulation based on the current evidence. BioMed Central 2020-09-14 /pmc/articles/PMC7487447/ /pubmed/32939266 http://dx.doi.org/10.1186/s40560-020-00483-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Mondal, Samhati
Quintili, Ashley L.
Karamchandani, Kunal
Bose, Somnath
Thromboembolic disease in COVID-19 patients: A brief narrative review
title Thromboembolic disease in COVID-19 patients: A brief narrative review
title_full Thromboembolic disease in COVID-19 patients: A brief narrative review
title_fullStr Thromboembolic disease in COVID-19 patients: A brief narrative review
title_full_unstemmed Thromboembolic disease in COVID-19 patients: A brief narrative review
title_short Thromboembolic disease in COVID-19 patients: A brief narrative review
title_sort thromboembolic disease in covid-19 patients: a brief narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487447/
https://www.ncbi.nlm.nih.gov/pubmed/32939266
http://dx.doi.org/10.1186/s40560-020-00483-y
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