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A nicotine-induced positive feedback loop between HIF1A and YAP1 contributes to epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma

BACKGROUND: Nicotine, an active ingredient in tobacco, can promote epithelial-to-mesenchymal transition (EMT) processes that enhance the aggressiveness of a number of human cancers. In the present study, we investigated whether cigarette smoke/nicotine drives EMT in pancreatic ductal adenocarcinoma...

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Detalles Bibliográficos
Autores principales:	Ben, Qiwen, An, Wei, Sun, Yunwei, Qian, Aihua, Liu, Jun, Zou, Duowu, Yuan, Yaozong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487530/ https://www.ncbi.nlm.nih.gov/pubmed/32894161 http://dx.doi.org/10.1186/s13046-020-01689-6

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