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Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein

BACKGROUND: α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson’s disease (PD). Mouse aSyn contains a threonine residue at position 53 that mimics the human familial PD substitution A53T, yet in contrast to A53...

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Detalles Bibliográficos
Autores principales:	Landeck, Natalie, Strathearn, Katherine E., Ysselstein, Daniel, Buck, Kerstin, Dutta, Sayan, Banerjee, Siddhartha, Lv, Zhengjian, Hulleman, John D., Hindupur, Jagadish, Lin, Li-Kai, Padalkar, Sonal, Stanciu, Lia A., Lyubchenko, Yuri L., Kirik, Deniz, Rochet, Jean-Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487555/ https://www.ncbi.nlm.nih.gov/pubmed/32900375 http://dx.doi.org/10.1186/s13024-020-00380-w

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