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Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis

BACKGROUND: Disruption of β-amyloid (Aβ) homeostasis is the initial culprit in Alzheimer’s disease (AD) pathogenesis. Astrocytes respond to emerging Aβ plaques by altering their phenotype and function, yet molecular mechanisms governing astrocytic response and their precise role in countering Aβ dep...

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Detalles Bibliográficos
Autores principales:	Pankiewicz, Joanna E., Diaz, Jenny R., Martá-Ariza, Mitchell, Lizińczyk, Anita M., Franco, Leor A., Sadowski, Martin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487614/ https://www.ncbi.nlm.nih.gov/pubmed/32907613 http://dx.doi.org/10.1186/s13024-020-00401-8

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