Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder

BACKGROUND: Valproate-induced hypothyroidism is a rare condition and has been considered asymptomatic. Here, we report a case of bipolar I disorder who developed symptomatic valproate-induced hypothyroidism. CASE PRESENTATION: A 44-year-old woman with bipolar I disorder complained of severe fatigue...

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Autores principales: Kanamori, Tadashi, Suzuki, Masahiro, Kaneko, Yoshiyuki, Yamada, Kouju, Kubo, Hideyuki, Uchiyama, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487638/
https://www.ncbi.nlm.nih.gov/pubmed/32944056
http://dx.doi.org/10.1186/s12991-020-00299-y
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author Kanamori, Tadashi
Suzuki, Masahiro
Kaneko, Yoshiyuki
Yamada, Kouju
Kubo, Hideyuki
Uchiyama, Makoto
author_facet Kanamori, Tadashi
Suzuki, Masahiro
Kaneko, Yoshiyuki
Yamada, Kouju
Kubo, Hideyuki
Uchiyama, Makoto
author_sort Kanamori, Tadashi
collection PubMed
description BACKGROUND: Valproate-induced hypothyroidism is a rare condition and has been considered asymptomatic. Here, we report a case of bipolar I disorder who developed symptomatic valproate-induced hypothyroidism. CASE PRESENTATION: A 44-year-old woman with bipolar I disorder complained of severe fatigue after starting valproate. She showed a hormonal pattern of central hypothyroidism. Thyroid autoantibodies were negative, and no pituitary abnormality was seen on magnetic resonance imaging. After stopping valproate, her severe fatigue rapidly improved with normalizing thyroid function. CONCLUSIONS: Our case suggests that valproate-induced hypothyroidism should be considered when patients complain of excessive fatigue under treatment with valproate.
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spelling pubmed-74876382020-09-16 Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder Kanamori, Tadashi Suzuki, Masahiro Kaneko, Yoshiyuki Yamada, Kouju Kubo, Hideyuki Uchiyama, Makoto Ann Gen Psychiatry Case Report BACKGROUND: Valproate-induced hypothyroidism is a rare condition and has been considered asymptomatic. Here, we report a case of bipolar I disorder who developed symptomatic valproate-induced hypothyroidism. CASE PRESENTATION: A 44-year-old woman with bipolar I disorder complained of severe fatigue after starting valproate. She showed a hormonal pattern of central hypothyroidism. Thyroid autoantibodies were negative, and no pituitary abnormality was seen on magnetic resonance imaging. After stopping valproate, her severe fatigue rapidly improved with normalizing thyroid function. CONCLUSIONS: Our case suggests that valproate-induced hypothyroidism should be considered when patients complain of excessive fatigue under treatment with valproate. BioMed Central 2020-09-05 /pmc/articles/PMC7487638/ /pubmed/32944056 http://dx.doi.org/10.1186/s12991-020-00299-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Kanamori, Tadashi
Suzuki, Masahiro
Kaneko, Yoshiyuki
Yamada, Kouju
Kubo, Hideyuki
Uchiyama, Makoto
Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder
title Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder
title_full Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder
title_fullStr Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder
title_full_unstemmed Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder
title_short Severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder
title_sort severe fatigue due to valproate-induced hypothyroidism in a case of bipolar disorder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487638/
https://www.ncbi.nlm.nih.gov/pubmed/32944056
http://dx.doi.org/10.1186/s12991-020-00299-y
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