Loss of FBXW7-mediated degradation of BRAF elicits resistance to BET inhibitors in adult T cell leukemia cells

BACKGROUND: Human T cell leukemia virus type 1 (HTLV-1)-associated adult T cell leukemia (ATL) has a very poor prognosis with a median survival of 8 months and a 4-year overall survival of 11% for acute ATL. Present treatment options are limited and there is no curative therapy for ATL. Ubiquitin li...

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Detalles Bibliográficos
Autores principales: Yeh, Chien-Hung, Bellon, Marcia, Wang, Fang, Zhang, Hong, Fu, Liwu, Nicot, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487643/
https://www.ncbi.nlm.nih.gov/pubmed/32907612
http://dx.doi.org/10.1186/s12943-020-01254-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487643/
https://www.ncbi.nlm.nih.gov/pubmed/32907612
http://dx.doi.org/10.1186/s12943-020-01254-x

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