Bayesian copy number detection and association in large-scale studies

BACKGROUND: Germline copy number variants (CNVs) increase risk for many diseases, yet detection of CNVs and quantifying their contribution to disease risk in large-scale studies is challenging due to biological and technical sources of heterogeneity that vary across the genome within and between sam...

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Detalles Bibliográficos
Autores principales: Cristiano, Stephen, McKean, David, Carey, Jacob, Bracci, Paige, Brennan, Paul, Chou, Michael, Du, Mengmeng, Gallinger, Steven, Goggins, Michael G., Hassan, Manal M., Hung, Rayjean J., Kurtz, Robert C., Li, Donghui, Lu, Lingeng, Neale, Rachel, Olson, Sara, Petersen, Gloria, Rabe, Kari G., Fu, Jack, Risch, Harvey, Rosner, Gary L., Ruczinski, Ingo, Klein, Alison P., Scharpf, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487704/
https://www.ncbi.nlm.nih.gov/pubmed/32894098
http://dx.doi.org/10.1186/s12885-020-07304-3

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