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AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience

Cortical plasticity improves behaviors and helps recover lost functions after injury. However, the underlying synaptic mechanisms remain unclear. In mice, we show that trimming all but one whisker enhances sensory responses from the spared whisker in the barrel cortex and occludes whisker-mediated s...

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Autores principales: Campelo, Tiago, Augusto, Elisabete, Chenouard, Nicolas, de Miranda, Aron, Kouskoff, Vladimir, Camus, Come, Choquet, Daniel, Gambino, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487777/
https://www.ncbi.nlm.nih.gov/pubmed/32877679
http://dx.doi.org/10.1016/j.celrep.2020.108097
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author Campelo, Tiago
Augusto, Elisabete
Chenouard, Nicolas
de Miranda, Aron
Kouskoff, Vladimir
Camus, Come
Choquet, Daniel
Gambino, Frédéric
author_facet Campelo, Tiago
Augusto, Elisabete
Chenouard, Nicolas
de Miranda, Aron
Kouskoff, Vladimir
Camus, Come
Choquet, Daniel
Gambino, Frédéric
author_sort Campelo, Tiago
collection PubMed
description Cortical plasticity improves behaviors and helps recover lost functions after injury. However, the underlying synaptic mechanisms remain unclear. In mice, we show that trimming all but one whisker enhances sensory responses from the spared whisker in the barrel cortex and occludes whisker-mediated synaptic potentiation (w-Pot) in vivo. In addition, whisker-dependent behaviors that are initially impaired by single-whisker experience (SWE) rapidly recover when associated cortical regions remap. Cross-linking the surface GluA2 subunit of AMPA receptors (AMPARs) suppresses the expression of w-Pot, presumably by blocking AMPAR surface diffusion, in mice with all whiskers intact, indicating that synaptic potentiation in vivo requires AMPAR trafficking. We use this approach to demonstrate that w-Pot is required for SWE-mediated strengthening of synaptic inputs and initiates the recovery of previously learned skills during the early phases of SWE. Taken together, our data reveal that w-Pot mediates cortical remapping and behavioral improvement upon partial sensory deafferentation.
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spelling pubmed-74877772020-09-18 AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience Campelo, Tiago Augusto, Elisabete Chenouard, Nicolas de Miranda, Aron Kouskoff, Vladimir Camus, Come Choquet, Daniel Gambino, Frédéric Cell Rep Article Cortical plasticity improves behaviors and helps recover lost functions after injury. However, the underlying synaptic mechanisms remain unclear. In mice, we show that trimming all but one whisker enhances sensory responses from the spared whisker in the barrel cortex and occludes whisker-mediated synaptic potentiation (w-Pot) in vivo. In addition, whisker-dependent behaviors that are initially impaired by single-whisker experience (SWE) rapidly recover when associated cortical regions remap. Cross-linking the surface GluA2 subunit of AMPA receptors (AMPARs) suppresses the expression of w-Pot, presumably by blocking AMPAR surface diffusion, in mice with all whiskers intact, indicating that synaptic potentiation in vivo requires AMPAR trafficking. We use this approach to demonstrate that w-Pot is required for SWE-mediated strengthening of synaptic inputs and initiates the recovery of previously learned skills during the early phases of SWE. Taken together, our data reveal that w-Pot mediates cortical remapping and behavioral improvement upon partial sensory deafferentation. Cell Press 2020-09-01 /pmc/articles/PMC7487777/ /pubmed/32877679 http://dx.doi.org/10.1016/j.celrep.2020.108097 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Campelo, Tiago
Augusto, Elisabete
Chenouard, Nicolas
de Miranda, Aron
Kouskoff, Vladimir
Camus, Come
Choquet, Daniel
Gambino, Frédéric
AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience
title AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience
title_full AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience
title_fullStr AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience
title_full_unstemmed AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience
title_short AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience
title_sort ampar-dependent synaptic plasticity initiates cortical remapping and adaptive behaviors during sensory experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487777/
https://www.ncbi.nlm.nih.gov/pubmed/32877679
http://dx.doi.org/10.1016/j.celrep.2020.108097
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