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AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience
Cortical plasticity improves behaviors and helps recover lost functions after injury. However, the underlying synaptic mechanisms remain unclear. In mice, we show that trimming all but one whisker enhances sensory responses from the spared whisker in the barrel cortex and occludes whisker-mediated s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487777/ https://www.ncbi.nlm.nih.gov/pubmed/32877679 http://dx.doi.org/10.1016/j.celrep.2020.108097 |
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author | Campelo, Tiago Augusto, Elisabete Chenouard, Nicolas de Miranda, Aron Kouskoff, Vladimir Camus, Come Choquet, Daniel Gambino, Frédéric |
author_facet | Campelo, Tiago Augusto, Elisabete Chenouard, Nicolas de Miranda, Aron Kouskoff, Vladimir Camus, Come Choquet, Daniel Gambino, Frédéric |
author_sort | Campelo, Tiago |
collection | PubMed |
description | Cortical plasticity improves behaviors and helps recover lost functions after injury. However, the underlying synaptic mechanisms remain unclear. In mice, we show that trimming all but one whisker enhances sensory responses from the spared whisker in the barrel cortex and occludes whisker-mediated synaptic potentiation (w-Pot) in vivo. In addition, whisker-dependent behaviors that are initially impaired by single-whisker experience (SWE) rapidly recover when associated cortical regions remap. Cross-linking the surface GluA2 subunit of AMPA receptors (AMPARs) suppresses the expression of w-Pot, presumably by blocking AMPAR surface diffusion, in mice with all whiskers intact, indicating that synaptic potentiation in vivo requires AMPAR trafficking. We use this approach to demonstrate that w-Pot is required for SWE-mediated strengthening of synaptic inputs and initiates the recovery of previously learned skills during the early phases of SWE. Taken together, our data reveal that w-Pot mediates cortical remapping and behavioral improvement upon partial sensory deafferentation. |
format | Online Article Text |
id | pubmed-7487777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-74877772020-09-18 AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience Campelo, Tiago Augusto, Elisabete Chenouard, Nicolas de Miranda, Aron Kouskoff, Vladimir Camus, Come Choquet, Daniel Gambino, Frédéric Cell Rep Article Cortical plasticity improves behaviors and helps recover lost functions after injury. However, the underlying synaptic mechanisms remain unclear. In mice, we show that trimming all but one whisker enhances sensory responses from the spared whisker in the barrel cortex and occludes whisker-mediated synaptic potentiation (w-Pot) in vivo. In addition, whisker-dependent behaviors that are initially impaired by single-whisker experience (SWE) rapidly recover when associated cortical regions remap. Cross-linking the surface GluA2 subunit of AMPA receptors (AMPARs) suppresses the expression of w-Pot, presumably by blocking AMPAR surface diffusion, in mice with all whiskers intact, indicating that synaptic potentiation in vivo requires AMPAR trafficking. We use this approach to demonstrate that w-Pot is required for SWE-mediated strengthening of synaptic inputs and initiates the recovery of previously learned skills during the early phases of SWE. Taken together, our data reveal that w-Pot mediates cortical remapping and behavioral improvement upon partial sensory deafferentation. Cell Press 2020-09-01 /pmc/articles/PMC7487777/ /pubmed/32877679 http://dx.doi.org/10.1016/j.celrep.2020.108097 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Campelo, Tiago Augusto, Elisabete Chenouard, Nicolas de Miranda, Aron Kouskoff, Vladimir Camus, Come Choquet, Daniel Gambino, Frédéric AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience |
title | AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience |
title_full | AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience |
title_fullStr | AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience |
title_full_unstemmed | AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience |
title_short | AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience |
title_sort | ampar-dependent synaptic plasticity initiates cortical remapping and adaptive behaviors during sensory experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487777/ https://www.ncbi.nlm.nih.gov/pubmed/32877679 http://dx.doi.org/10.1016/j.celrep.2020.108097 |
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