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Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation
BACKGROUND: Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of patients...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487841/ https://www.ncbi.nlm.nih.gov/pubmed/32891156 http://dx.doi.org/10.1186/s12955-020-01505-x |
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author | Meys, Roy Stoffels, Anouk A. F. Houben-Wilke, Sarah Janssen, Daisy J. A. Burtin, Chris van Hees, Hieronymus W. H. Franssen, Frits M. E. van den Borst, Bram Wouters, Emiel F. M. Spruit, Martijn A. |
author_facet | Meys, Roy Stoffels, Anouk A. F. Houben-Wilke, Sarah Janssen, Daisy J. A. Burtin, Chris van Hees, Hieronymus W. H. Franssen, Frits M. E. van den Borst, Bram Wouters, Emiel F. M. Spruit, Martijn A. |
author_sort | Meys, Roy |
collection | PubMed |
description | BACKGROUND: Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of patients with COPD, the current study aimed to assess the association between different exercise test outcomes and PROs, before and after pulmonary rehabilitation (PR). METHODS: Correlations between PROs used to describe health-related quality of life (HRQoL), mood status, level of care dependency and dyspnea in patients with COPD and commonly used laboratory- and field-based exercise test outcomes were evaluated in 518 individuals with COPD attending PR. RESULTS: Overall, correlations between PROs and exercise test outcomes at baseline were statistically significant. The correlation between modified Medical Research Council (mMRC) dyspnea score and 6-min walking distance (6MWD) was strongest (ρ:-0.65; p<0.001). HRQoL related PROs showed weak correlations with exercise outcomes at baseline. Moderate correlations were found between St George’s Respiratory Questionnaire total score and 6MWD (r:-0.53; p<0.001) and maximal workload achieved during cardiopulmonary exercise testing (ρ:-0.48; p<0.001); and between Clinical COPD Questionnaire (CCQ) total score and 6MWD (r:-0.48; p<0.001) and maximal workload (ρ:-0.43; p<0.001). When significant, correlations between changes in exercise test outcomes and changes in PROs after PR were generally very weak or weak. The highest correlation was found between changes in CCQ total score and changes in 6MWD (ρ: − 0.36; p<0.001). CONCLUSIONS: PROs and exercise test outcomes, although significantly correlated with each other, assess different disease features in patients with COPD. Individual PROs need to be supported by additional functional measurements whenever possible, in order to get a more detailed insight in the effectiveness of a PR program. TRIAL REGISTRATION: Netherlands Trial Register (NL3263/NTR3416). Registered 2 May 2012. |
format | Online Article Text |
id | pubmed-7487841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74878412020-09-16 Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation Meys, Roy Stoffels, Anouk A. F. Houben-Wilke, Sarah Janssen, Daisy J. A. Burtin, Chris van Hees, Hieronymus W. H. Franssen, Frits M. E. van den Borst, Bram Wouters, Emiel F. M. Spruit, Martijn A. Health Qual Life Outcomes Research BACKGROUND: Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of patients with COPD, the current study aimed to assess the association between different exercise test outcomes and PROs, before and after pulmonary rehabilitation (PR). METHODS: Correlations between PROs used to describe health-related quality of life (HRQoL), mood status, level of care dependency and dyspnea in patients with COPD and commonly used laboratory- and field-based exercise test outcomes were evaluated in 518 individuals with COPD attending PR. RESULTS: Overall, correlations between PROs and exercise test outcomes at baseline were statistically significant. The correlation between modified Medical Research Council (mMRC) dyspnea score and 6-min walking distance (6MWD) was strongest (ρ:-0.65; p<0.001). HRQoL related PROs showed weak correlations with exercise outcomes at baseline. Moderate correlations were found between St George’s Respiratory Questionnaire total score and 6MWD (r:-0.53; p<0.001) and maximal workload achieved during cardiopulmonary exercise testing (ρ:-0.48; p<0.001); and between Clinical COPD Questionnaire (CCQ) total score and 6MWD (r:-0.48; p<0.001) and maximal workload (ρ:-0.43; p<0.001). When significant, correlations between changes in exercise test outcomes and changes in PROs after PR were generally very weak or weak. The highest correlation was found between changes in CCQ total score and changes in 6MWD (ρ: − 0.36; p<0.001). CONCLUSIONS: PROs and exercise test outcomes, although significantly correlated with each other, assess different disease features in patients with COPD. Individual PROs need to be supported by additional functional measurements whenever possible, in order to get a more detailed insight in the effectiveness of a PR program. TRIAL REGISTRATION: Netherlands Trial Register (NL3263/NTR3416). Registered 2 May 2012. BioMed Central 2020-09-05 /pmc/articles/PMC7487841/ /pubmed/32891156 http://dx.doi.org/10.1186/s12955-020-01505-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Meys, Roy Stoffels, Anouk A. F. Houben-Wilke, Sarah Janssen, Daisy J. A. Burtin, Chris van Hees, Hieronymus W. H. Franssen, Frits M. E. van den Borst, Bram Wouters, Emiel F. M. Spruit, Martijn A. Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
title | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
title_full | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
title_fullStr | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
title_full_unstemmed | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
title_short | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
title_sort | association between patient-reported outcomes and exercise test outcomes in patients with copd before and after pulmonary rehabilitation |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487841/ https://www.ncbi.nlm.nih.gov/pubmed/32891156 http://dx.doi.org/10.1186/s12955-020-01505-x |
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