Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis

BACKGROUND: Inactivation of the tumor suppressor p53 is critical for pathogenesis of glioma, in particular glioblastoma multiforme (GBM). MDM2, the main negative regulator of p53, binds to and forms a stable complex with p53 to regulate its activity. Hitherto, it is unclear whether the stability of...

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Detalles Bibliográficos
Autores principales: Lou, Jiacheng, Hao, Yuchao, Lin, Kefeng, Lyu, Yizhu, Chen, Meiwei, Wang, Han, Zou, Deyu, Jiang, Xuewen, Wang, Renchun, Jin, Di, Lam, Eric W.-F., Shao, Shujuan, Liu, Quentin, Yan, Jinsong, Wang, Xiang, Chen, Puxiang, Zhang, Bo, Jin, Bilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487905/
https://www.ncbi.nlm.nih.gov/pubmed/32894144
http://dx.doi.org/10.1186/s12943-020-01253-y

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