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A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells

BACKGROUND: Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4(+) T-lymphocytes and evoques severe diseases, predominantly Adult T-Cell Leukemia/ Lymphoma (ATL/L) and HTLV-1-associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP). The viral transactivator of the pX region (Tax)...

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Detalles Bibliográficos
Autores principales:	Millen, Sebastian, Meretuk, Lina, Göttlicher, Tim, Schmitt, Sarah, Fleckenstein, Bernhard, Thoma-Kress, Andrea K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488018/ https://www.ncbi.nlm.nih.gov/pubmed/32912211 http://dx.doi.org/10.1186/s12977-020-00538-w

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