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Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?

BACKGROUND: Ultrasonography is commonly used to diagnose left ventricular noncompaction (LVNC). A ratio of noncompacted to compacted myocardium (NC/C ratio) > >2 is often used to diagnose LVNC. However, a large proportion of patients with noncompact myocardium have NC/C < 2, and the prognos...

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Autores principales: Gan, Yi, Luo, Li, Tian, Jie, Liu, Lingjuan, Lu, Tiewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488020/
https://www.ncbi.nlm.nih.gov/pubmed/32907541
http://dx.doi.org/10.1186/s12887-020-02312-5
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author Gan, Yi
Luo, Li
Tian, Jie
Liu, Lingjuan
Lu, Tiewei
author_facet Gan, Yi
Luo, Li
Tian, Jie
Liu, Lingjuan
Lu, Tiewei
author_sort Gan, Yi
collection PubMed
description BACKGROUND: Ultrasonography is commonly used to diagnose left ventricular noncompaction (LVNC). A ratio of noncompacted to compacted myocardium (NC/C ratio) > >2 is often used to diagnose LVNC. However, a large proportion of patients with noncompact myocardium have NC/C < 2, and the prognosis of these patients have not been studied. METHODS: We included children diagnosed with LVNC between 0 and 15 years of age from January 2007 to December 2018. LVNC was diagnosed based on Stöllberger standard when over three trabeculae were found to be associated with the interventricular recesses. A maximal end systolic ratio of noncompacted to compacted layers was NC/C ratio. Outcomes for LVNC subjects with NC/C < 2 and NC/C > 2 were compared using Kaplan-Meier methods. RESULTS: There were 124 newly diagnosed LVNC cases, classified as isolated (i-LVNC, n = 47) or non-isolated (ni-LVNC, n = 77) LVNC and NC/C > 2 (n = 43) or < 2 (n = 81). The median (interquartile range) follow-up duration was 12 (3–30) months for all patients and 16 (6–36) months for survivors. Sixteen patients with i-LVNC died during follow-up. Patients with i-LVNC and NC/C > 2 had worse survival than those with NC/C < 2 (p = 0.022). CONCLUSIONS: In conclusion, during a 12-month follow-up, patients with i-LVNC with NC/C < 2 had a benign prognosis and better outcomes than those with NC/C > 2, suggesting that the former could have a more active and routine lifestyle.
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spelling pubmed-74880202020-09-16 Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis? Gan, Yi Luo, Li Tian, Jie Liu, Lingjuan Lu, Tiewei BMC Pediatr Research Article BACKGROUND: Ultrasonography is commonly used to diagnose left ventricular noncompaction (LVNC). A ratio of noncompacted to compacted myocardium (NC/C ratio) > >2 is often used to diagnose LVNC. However, a large proportion of patients with noncompact myocardium have NC/C < 2, and the prognosis of these patients have not been studied. METHODS: We included children diagnosed with LVNC between 0 and 15 years of age from January 2007 to December 2018. LVNC was diagnosed based on Stöllberger standard when over three trabeculae were found to be associated with the interventricular recesses. A maximal end systolic ratio of noncompacted to compacted layers was NC/C ratio. Outcomes for LVNC subjects with NC/C < 2 and NC/C > 2 were compared using Kaplan-Meier methods. RESULTS: There were 124 newly diagnosed LVNC cases, classified as isolated (i-LVNC, n = 47) or non-isolated (ni-LVNC, n = 77) LVNC and NC/C > 2 (n = 43) or < 2 (n = 81). The median (interquartile range) follow-up duration was 12 (3–30) months for all patients and 16 (6–36) months for survivors. Sixteen patients with i-LVNC died during follow-up. Patients with i-LVNC and NC/C > 2 had worse survival than those with NC/C < 2 (p = 0.022). CONCLUSIONS: In conclusion, during a 12-month follow-up, patients with i-LVNC with NC/C < 2 had a benign prognosis and better outcomes than those with NC/C > 2, suggesting that the former could have a more active and routine lifestyle. BioMed Central 2020-09-09 /pmc/articles/PMC7488020/ /pubmed/32907541 http://dx.doi.org/10.1186/s12887-020-02312-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Gan, Yi
Luo, Li
Tian, Jie
Liu, Lingjuan
Lu, Tiewei
Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?
title Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?
title_full Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?
title_fullStr Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?
title_full_unstemmed Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?
title_short Do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?
title_sort do children with left ventricular noncompaction and a noncompaction-to-compaction ratio < 2 have a better prognosis?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488020/
https://www.ncbi.nlm.nih.gov/pubmed/32907541
http://dx.doi.org/10.1186/s12887-020-02312-5
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