Cargando…
The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models
BACKGROUND: Osteoarthritis (OA), though being treated via various methods and medicines, is still a major healthcare concern mostly due to the increase in diagnosis of these age-related diseases. The present study aimed at investigating the effects of oral and intra articular injection of grape seed...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488061/ https://www.ncbi.nlm.nih.gov/pubmed/32912277 http://dx.doi.org/10.1186/s13018-020-01932-y |
_version_ | 1783581617840717824 |
---|---|
author | Tanideh, Nader Ashkani-Esfahani, Soheil Sadeghi, Farid Koohi-Hosseinabadi, Omid Irajie, Cambyz Iraji, Aida Lubberts, Bart Mohammadi Samani, Soleiman |
author_facet | Tanideh, Nader Ashkani-Esfahani, Soheil Sadeghi, Farid Koohi-Hosseinabadi, Omid Irajie, Cambyz Iraji, Aida Lubberts, Bart Mohammadi Samani, Soleiman |
author_sort | Tanideh, Nader |
collection | PubMed |
description | BACKGROUND: Osteoarthritis (OA), though being treated via various methods and medicines, is still a major healthcare concern mostly due to the increase in diagnosis of these age-related diseases. The present study aimed at investigating the effects of oral and intra articular injection of grape seed oil on OA in male rat models. METHODS AND MATERIALS: Seventy male rats were selected and their anterior cruciate ligament was cut to induce OA. They were divided into 7 groups (n = 10): C1, no treatment; C2, receiving 300 mg/day of Piascledine per os (PO); C3, 1 mg sodium hyaluronate intra-articularly in days 1, 7, 14; C4, 1 mg methyl-prednisolone acetate intra-articularly; E1, avocado and grape seed oil combination (2:1, 300 mg/day) PO; E2, 500 mg/day of grape seed oil PO; E3, 200 mg/day grape seed oil intra-articularly. After 10 weeks, the rats were anesthetized and evaluated radiologically and histopathologically. P value ≤ 0.05 was considered as statistically significant. RESULTS: All the groups made significant differences with C1 regarding all inspected radiological criteria (P ≤ 0.05). E1 and E3 showed significantly better effects on medial femoral condyle, medial tibial condyle, joint space width, total osteophyte, and OA scores (P ≤ 0.04). Joint surface, matrix, cell distribution, cell population viability, calcification, and subchondral bone in treatment groups had significantly better scores versus C1 (P ≤ 0.04). E1 and E3 had significantly superior results regarding joint surface, cell viability, and calcification (P ≤ 0.04). CONCLUSIONS: Grape seed oil has protective effects, both in injectable form and PO in combination with avocado, on OA in rats. Further clinical trials are necessary. |
format | Online Article Text |
id | pubmed-7488061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74880612020-09-16 The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models Tanideh, Nader Ashkani-Esfahani, Soheil Sadeghi, Farid Koohi-Hosseinabadi, Omid Irajie, Cambyz Iraji, Aida Lubberts, Bart Mohammadi Samani, Soleiman J Orthop Surg Res Research Article BACKGROUND: Osteoarthritis (OA), though being treated via various methods and medicines, is still a major healthcare concern mostly due to the increase in diagnosis of these age-related diseases. The present study aimed at investigating the effects of oral and intra articular injection of grape seed oil on OA in male rat models. METHODS AND MATERIALS: Seventy male rats were selected and their anterior cruciate ligament was cut to induce OA. They were divided into 7 groups (n = 10): C1, no treatment; C2, receiving 300 mg/day of Piascledine per os (PO); C3, 1 mg sodium hyaluronate intra-articularly in days 1, 7, 14; C4, 1 mg methyl-prednisolone acetate intra-articularly; E1, avocado and grape seed oil combination (2:1, 300 mg/day) PO; E2, 500 mg/day of grape seed oil PO; E3, 200 mg/day grape seed oil intra-articularly. After 10 weeks, the rats were anesthetized and evaluated radiologically and histopathologically. P value ≤ 0.05 was considered as statistically significant. RESULTS: All the groups made significant differences with C1 regarding all inspected radiological criteria (P ≤ 0.05). E1 and E3 showed significantly better effects on medial femoral condyle, medial tibial condyle, joint space width, total osteophyte, and OA scores (P ≤ 0.04). Joint surface, matrix, cell distribution, cell population viability, calcification, and subchondral bone in treatment groups had significantly better scores versus C1 (P ≤ 0.04). E1 and E3 had significantly superior results regarding joint surface, cell viability, and calcification (P ≤ 0.04). CONCLUSIONS: Grape seed oil has protective effects, both in injectable form and PO in combination with avocado, on OA in rats. Further clinical trials are necessary. BioMed Central 2020-09-10 /pmc/articles/PMC7488061/ /pubmed/32912277 http://dx.doi.org/10.1186/s13018-020-01932-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Tanideh, Nader Ashkani-Esfahani, Soheil Sadeghi, Farid Koohi-Hosseinabadi, Omid Irajie, Cambyz Iraji, Aida Lubberts, Bart Mohammadi Samani, Soleiman The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models |
title | The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models |
title_full | The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models |
title_fullStr | The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models |
title_full_unstemmed | The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models |
title_short | The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models |
title_sort | protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488061/ https://www.ncbi.nlm.nih.gov/pubmed/32912277 http://dx.doi.org/10.1186/s13018-020-01932-y |
work_keys_str_mv | AT tanidehnader theprotectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT ashkaniesfahanisoheil theprotectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT sadeghifarid theprotectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT koohihosseinabadiomid theprotectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT irajiecambyz theprotectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT irajiaida theprotectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT lubbertsbart theprotectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT mohammadisamanisoleiman theprotectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT tanidehnader protectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT ashkaniesfahanisoheil protectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT sadeghifarid protectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT koohihosseinabadiomid protectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT irajiecambyz protectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT irajiaida protectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT lubbertsbart protectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels AT mohammadisamanisoleiman protectiveeffectsofgrapeseedoiloninducedosteoarthritisofthekneeinmaleratmodels |