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Laboratory abnormalities in children with novel Coronavirus Disease 2019

The novel Coronavirus disease 2019 continues to be a worldwide pandemic. Yet, little is still known about the biological features of this emergent infection in children. In this prospective study, we collected 68 children infected with SARS-COV-2 from March 2020 to May 2020, in Marrakesh, Morocco. N...

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Autores principales: Bourkhissi, Laila, Fakiri, Karima EL, Nassih, Houda, Qadiry, Rabiy EL, Bourrahouat, Aicha, Ait Sab, Imane, Rada, Noureddine, Draiss, Ghizlane, Bouskraoui, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488170/
https://www.ncbi.nlm.nih.gov/pubmed/32958991
http://dx.doi.org/10.1177/1179556520955177
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author Bourkhissi, Laila
Fakiri, Karima EL
Nassih, Houda
Qadiry, Rabiy EL
Bourrahouat, Aicha
Ait Sab, Imane
Rada, Noureddine
Draiss, Ghizlane
Bouskraoui, Mohammed
author_facet Bourkhissi, Laila
Fakiri, Karima EL
Nassih, Houda
Qadiry, Rabiy EL
Bourrahouat, Aicha
Ait Sab, Imane
Rada, Noureddine
Draiss, Ghizlane
Bouskraoui, Mohammed
author_sort Bourkhissi, Laila
collection PubMed
description The novel Coronavirus disease 2019 continues to be a worldwide pandemic. Yet, little is still known about the biological features of this emergent infection in children. In this prospective study, we collected 68 children infected with SARS-COV-2 from March 2020 to May 2020, in Marrakesh, Morocco. No severe cases were observed in this cohort, and 66% of the patients were asymptomatic. The main laboratory abnormalities were hematological, as we found Leucopoenia in 4.4% of the cases, hyperleukocytosis in 1.6%. Neutropenia was found in 5 patients (7%) and only 2 cases (3%) had Lymphopenia. The inflammation and coagulation biomarkers were normal in the majority of the cases, as for liver and kidney function. Lactate dehydrogenase (LDH) serum levels were elevated in 8 cases (11.67%). The COVID-19 in children seems to have mild course and better outcome than in adults, which impacts the laboratory findings in this category. More studies must be conducted to learn more about the laboratory abnormalities in pediatric COVID-19.
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spelling pubmed-74881702020-09-14 Laboratory abnormalities in children with novel Coronavirus Disease 2019 Bourkhissi, Laila Fakiri, Karima EL Nassih, Houda Qadiry, Rabiy EL Bourrahouat, Aicha Ait Sab, Imane Rada, Noureddine Draiss, Ghizlane Bouskraoui, Mohammed Clin Med Insights Pediatr Original Research The novel Coronavirus disease 2019 continues to be a worldwide pandemic. Yet, little is still known about the biological features of this emergent infection in children. In this prospective study, we collected 68 children infected with SARS-COV-2 from March 2020 to May 2020, in Marrakesh, Morocco. No severe cases were observed in this cohort, and 66% of the patients were asymptomatic. The main laboratory abnormalities were hematological, as we found Leucopoenia in 4.4% of the cases, hyperleukocytosis in 1.6%. Neutropenia was found in 5 patients (7%) and only 2 cases (3%) had Lymphopenia. The inflammation and coagulation biomarkers were normal in the majority of the cases, as for liver and kidney function. Lactate dehydrogenase (LDH) serum levels were elevated in 8 cases (11.67%). The COVID-19 in children seems to have mild course and better outcome than in adults, which impacts the laboratory findings in this category. More studies must be conducted to learn more about the laboratory abnormalities in pediatric COVID-19. SAGE Publications 2020-09-11 /pmc/articles/PMC7488170/ /pubmed/32958991 http://dx.doi.org/10.1177/1179556520955177 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Bourkhissi, Laila
Fakiri, Karima EL
Nassih, Houda
Qadiry, Rabiy EL
Bourrahouat, Aicha
Ait Sab, Imane
Rada, Noureddine
Draiss, Ghizlane
Bouskraoui, Mohammed
Laboratory abnormalities in children with novel Coronavirus Disease 2019
title Laboratory abnormalities in children with novel Coronavirus Disease 2019
title_full Laboratory abnormalities in children with novel Coronavirus Disease 2019
title_fullStr Laboratory abnormalities in children with novel Coronavirus Disease 2019
title_full_unstemmed Laboratory abnormalities in children with novel Coronavirus Disease 2019
title_short Laboratory abnormalities in children with novel Coronavirus Disease 2019
title_sort laboratory abnormalities in children with novel coronavirus disease 2019
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488170/
https://www.ncbi.nlm.nih.gov/pubmed/32958991
http://dx.doi.org/10.1177/1179556520955177
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