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Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy
PURPOSE: Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome manifesting with visuospatial processing impairment. We recently suggested that abnormal population receptive field properties are associated with the symptoms of PCA patients. Specifically, simultanagnosia, the inability...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488212/ https://www.ncbi.nlm.nih.gov/pubmed/32897377 http://dx.doi.org/10.1167/iovs.61.11.8 |
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author | de Best, Pieter B. Abulafia, Ruth McKyton, Ayelet Levin, Netta |
author_facet | de Best, Pieter B. Abulafia, Ruth McKyton, Ayelet Levin, Netta |
author_sort | de Best, Pieter B. |
collection | PubMed |
description | PURPOSE: Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome manifesting with visuospatial processing impairment. We recently suggested that abnormal population receptive field properties are associated with the symptoms of PCA patients. Specifically, simultanagnosia, the inability to perceive multiple items simultaneously, can be explained by smaller peripheral population receptive fields, and foveal crowding, in which nearby distractors interfere with object perception, may result from larger foveal population receptive fields. These effects occurred predominantly in V1, even though atrophy mainly involves high-order areas. In this study, we used connective field modeling to better understand these inter-area interactions. METHODS: We used functional magnetic resonance imaging to scan six PCA patients and eight controls while they viewed drifting bar stimuli. Resting-state data were also collected. Connective field modeling was applied for both conditions: once when the source was V1 and the targets were extrastriate areas and once for the opposite direction. The difference between the two was defined as convergence magnitude. RESULTS: With stimulus, the convergence magnitude of the controls increased along the visual pathway, suggesting that spatial integration from V1 becomes larger up the visual hierarchy. No such slope was found in the PCA patients. The difference between the groups originated mainly from the dorsal pathway. Without stimulus, the convergence magnitude was negative, slightly more so for the PCA patients, with no slope, suggesting constant divergence along the visual hierarchy. CONCLUSIONS: Atrophy in one part of the visual system can affect other areas within the network through complex intervisual area interactions, resulting in modulation of population receptive field properties and an ensemble of visuocognitive function impairments. |
format | Online Article Text |
id | pubmed-7488212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-74882122020-09-23 Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy de Best, Pieter B. Abulafia, Ruth McKyton, Ayelet Levin, Netta Invest Ophthalmol Vis Sci Visual Neuroscience PURPOSE: Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome manifesting with visuospatial processing impairment. We recently suggested that abnormal population receptive field properties are associated with the symptoms of PCA patients. Specifically, simultanagnosia, the inability to perceive multiple items simultaneously, can be explained by smaller peripheral population receptive fields, and foveal crowding, in which nearby distractors interfere with object perception, may result from larger foveal population receptive fields. These effects occurred predominantly in V1, even though atrophy mainly involves high-order areas. In this study, we used connective field modeling to better understand these inter-area interactions. METHODS: We used functional magnetic resonance imaging to scan six PCA patients and eight controls while they viewed drifting bar stimuli. Resting-state data were also collected. Connective field modeling was applied for both conditions: once when the source was V1 and the targets were extrastriate areas and once for the opposite direction. The difference between the two was defined as convergence magnitude. RESULTS: With stimulus, the convergence magnitude of the controls increased along the visual pathway, suggesting that spatial integration from V1 becomes larger up the visual hierarchy. No such slope was found in the PCA patients. The difference between the groups originated mainly from the dorsal pathway. Without stimulus, the convergence magnitude was negative, slightly more so for the PCA patients, with no slope, suggesting constant divergence along the visual hierarchy. CONCLUSIONS: Atrophy in one part of the visual system can affect other areas within the network through complex intervisual area interactions, resulting in modulation of population receptive field properties and an ensemble of visuocognitive function impairments. The Association for Research in Vision and Ophthalmology 2020-09-08 /pmc/articles/PMC7488212/ /pubmed/32897377 http://dx.doi.org/10.1167/iovs.61.11.8 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Visual Neuroscience de Best, Pieter B. Abulafia, Ruth McKyton, Ayelet Levin, Netta Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy |
title | Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy |
title_full | Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy |
title_fullStr | Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy |
title_full_unstemmed | Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy |
title_short | Convergence Along the Visual Hierarchy Is Altered in Posterior Cortical Atrophy |
title_sort | convergence along the visual hierarchy is altered in posterior cortical atrophy |
topic | Visual Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488212/ https://www.ncbi.nlm.nih.gov/pubmed/32897377 http://dx.doi.org/10.1167/iovs.61.11.8 |
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