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Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology
BACKGROUND: This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. METHODS: Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488236/ https://www.ncbi.nlm.nih.gov/pubmed/32912249 http://dx.doi.org/10.1186/s13000-020-01027-6 |
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author | Sukegawa, Shintaro Ono, Sawako Nakano, Keisuke Takabatake, Kiyofumi Kawai, Hotaka Nagatsuka, Hitoshi Furuki, Yoshihiko |
author_facet | Sukegawa, Shintaro Ono, Sawako Nakano, Keisuke Takabatake, Kiyofumi Kawai, Hotaka Nagatsuka, Hitoshi Furuki, Yoshihiko |
author_sort | Sukegawa, Shintaro |
collection | PubMed |
description | BACKGROUND: This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. METHODS: Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological diagnostic results were compared with histology results. RESULTS: Of NILM cytology cases, the most frequent case was negative [LBC n = 50 (90.9%), conventional n = 22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was negative (LBC n = 34; 75.6%, conventional n = 14; 70.0%). Among OHSIL cytodiagnoses (LBC n = 51, conventional n = 23), SCC was the most frequent (LBC n = 31; 60.8%, conventional n = 7; 30.4%). Negative cases were common (LBC n = 13; 25.5%, conventional n = 14; 60.9%). Among SCC cytodiagnoses SCC was the most common (LBC n = 16; 88.9%, conventional n = 14; 87.5%). Regarding the diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and false-negative rate of 20.6%/23.3%. CONCLUSIONS: LBC method was superior to conventional cytodiagnosis methods. It was especially superior for OLSIL and OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is necessary to make a comprehensive diagnosis considering the clinical findings. |
format | Online Article Text |
id | pubmed-7488236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74882362020-09-16 Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology Sukegawa, Shintaro Ono, Sawako Nakano, Keisuke Takabatake, Kiyofumi Kawai, Hotaka Nagatsuka, Hitoshi Furuki, Yoshihiko Diagn Pathol Research BACKGROUND: This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. METHODS: Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological diagnostic results were compared with histology results. RESULTS: Of NILM cytology cases, the most frequent case was negative [LBC n = 50 (90.9%), conventional n = 22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was negative (LBC n = 34; 75.6%, conventional n = 14; 70.0%). Among OHSIL cytodiagnoses (LBC n = 51, conventional n = 23), SCC was the most frequent (LBC n = 31; 60.8%, conventional n = 7; 30.4%). Negative cases were common (LBC n = 13; 25.5%, conventional n = 14; 60.9%). Among SCC cytodiagnoses SCC was the most common (LBC n = 16; 88.9%, conventional n = 14; 87.5%). Regarding the diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and false-negative rate of 20.6%/23.3%. CONCLUSIONS: LBC method was superior to conventional cytodiagnosis methods. It was especially superior for OLSIL and OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is necessary to make a comprehensive diagnosis considering the clinical findings. BioMed Central 2020-09-10 /pmc/articles/PMC7488236/ /pubmed/32912249 http://dx.doi.org/10.1186/s13000-020-01027-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Sukegawa, Shintaro Ono, Sawako Nakano, Keisuke Takabatake, Kiyofumi Kawai, Hotaka Nagatsuka, Hitoshi Furuki, Yoshihiko Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
title | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
title_full | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
title_fullStr | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
title_full_unstemmed | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
title_short | Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
title_sort | clinical study on primary screening of oral cancer and precancerous lesions by oral cytology |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488236/ https://www.ncbi.nlm.nih.gov/pubmed/32912249 http://dx.doi.org/10.1186/s13000-020-01027-6 |
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