Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring

Real-time medication monitoring (RTMM) may potentially enhance adherence to antiretroviral treatment (ART). We describe a participant in an ongoing trial who, shortly after completing trial participation, died of cryptococcal meningitis despite high levels of adherence according to self-report, pill...

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Autores principales: Ngowi, Kennedy Michael, Masika, Lydia, Lyamuya, Furaha, Muro, Eva, Mmbaga, Blandina T., Sprangers, Mirjam A. G., Nieuwkerk, Pythia T., Aarnoutse, Rob E., Reiss, Peter, Sumari-de Boer, I. Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488262/
https://www.ncbi.nlm.nih.gov/pubmed/32912282
http://dx.doi.org/10.1186/s12981-020-00313-z
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author Ngowi, Kennedy Michael
Masika, Lydia
Lyamuya, Furaha
Muro, Eva
Mmbaga, Blandina T.
Sprangers, Mirjam A. G.
Nieuwkerk, Pythia T.
Aarnoutse, Rob E.
Reiss, Peter
Sumari-de Boer, I. Marion
author_facet Ngowi, Kennedy Michael
Masika, Lydia
Lyamuya, Furaha
Muro, Eva
Mmbaga, Blandina T.
Sprangers, Mirjam A. G.
Nieuwkerk, Pythia T.
Aarnoutse, Rob E.
Reiss, Peter
Sumari-de Boer, I. Marion
author_sort Ngowi, Kennedy Michael
collection PubMed
description Real-time medication monitoring (RTMM) may potentially enhance adherence to antiretroviral treatment (ART). We describe a participant in an ongoing trial who, shortly after completing trial participation, died of cryptococcal meningitis despite high levels of adherence according to self-report, pill-counts and RTMM (> 99%). However, she evidenced consistently high HIV viral load throughout the 48-week study follow-up. Subsequently, her relatives unsolicitedly returned eight months’ dispensed ART medication that she was supposed to have taken. This brief report illustrates the challenges of adherence measurements including RTMM, and reinforces the need to combine adherence assessments with viral load monitoring in HIV care.
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spelling pubmed-74882622020-09-16 Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring Ngowi, Kennedy Michael Masika, Lydia Lyamuya, Furaha Muro, Eva Mmbaga, Blandina T. Sprangers, Mirjam A. G. Nieuwkerk, Pythia T. Aarnoutse, Rob E. Reiss, Peter Sumari-de Boer, I. Marion AIDS Res Ther Case Report Real-time medication monitoring (RTMM) may potentially enhance adherence to antiretroviral treatment (ART). We describe a participant in an ongoing trial who, shortly after completing trial participation, died of cryptococcal meningitis despite high levels of adherence according to self-report, pill-counts and RTMM (> 99%). However, she evidenced consistently high HIV viral load throughout the 48-week study follow-up. Subsequently, her relatives unsolicitedly returned eight months’ dispensed ART medication that she was supposed to have taken. This brief report illustrates the challenges of adherence measurements including RTMM, and reinforces the need to combine adherence assessments with viral load monitoring in HIV care. BioMed Central 2020-09-10 /pmc/articles/PMC7488262/ /pubmed/32912282 http://dx.doi.org/10.1186/s12981-020-00313-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Ngowi, Kennedy Michael
Masika, Lydia
Lyamuya, Furaha
Muro, Eva
Mmbaga, Blandina T.
Sprangers, Mirjam A. G.
Nieuwkerk, Pythia T.
Aarnoutse, Rob E.
Reiss, Peter
Sumari-de Boer, I. Marion
Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
title Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
title_full Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
title_fullStr Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
title_full_unstemmed Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
title_short Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
title_sort returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488262/
https://www.ncbi.nlm.nih.gov/pubmed/32912282
http://dx.doi.org/10.1186/s12981-020-00313-z
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