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Understanding and Improving the Membrane Permeability of VH032-Based PROTACs
[Image: see text] Proteolysis targeting chimeras (PROTACs) are catalytic heterobifunctional molecules that can selectively degrade a protein of interest by recruiting a ubiquitin E3 ligase to the target, leading to its ubiquitylation and degradation by the proteasome. Most degraders lie outside the...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488288/ https://www.ncbi.nlm.nih.gov/pubmed/32939229 http://dx.doi.org/10.1021/acsmedchemlett.0c00265 |