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MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of normal endothelium, leading to endothelial dysfunction which predisposes the patient to cardio...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488343/ https://www.ncbi.nlm.nih.gov/pubmed/32907629 http://dx.doi.org/10.1186/s12933-020-01107-3 |
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author | Ait-Aissa, Karima Nguyen, Quynh My Gabani, Mohanad Kassan, Adam Kumar, Santosh Choi, Soo-Kyoung Gonzalez, Alexis A. Khataei, Tahsin Sahyoun, Amal M. Chen, Cheng Kassan, Modar |
author_facet | Ait-Aissa, Karima Nguyen, Quynh My Gabani, Mohanad Kassan, Adam Kumar, Santosh Choi, Soo-Kyoung Gonzalez, Alexis A. Khataei, Tahsin Sahyoun, Amal M. Chen, Cheng Kassan, Modar |
author_sort | Ait-Aissa, Karima |
collection | PubMed |
description | The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of normal endothelium, leading to endothelial dysfunction which predisposes the patient to cardiovascular diseases. MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that play important roles in a variety of cellular processes such as differentiation, proliferation, apoptosis, and stress response; their alteration contributes to the development of many pathologies including obesity. Mediators of obesity-induced endothelial dysfunction include altered endothelial nitric oxide synthase (eNOS), Sirtuin 1 (SIRT1), oxidative stress, autophagy machinery and endoplasmic reticulum (ER) stress. All of these factors have been shown to be either directly or indirectly caused by gene regulatory mechanisms of miRNAs. In this review, we aim to provide a comprehensive description of the therapeutic potential of miRNAs to treat obesity-induced endothelial dysfunction. This may lead to the identification of new targets for interventions that may prevent or delay the development of obesity-related cardiovascular disease. |
format | Online Article Text |
id | pubmed-7488343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74883432020-09-16 MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy Ait-Aissa, Karima Nguyen, Quynh My Gabani, Mohanad Kassan, Adam Kumar, Santosh Choi, Soo-Kyoung Gonzalez, Alexis A. Khataei, Tahsin Sahyoun, Amal M. Chen, Cheng Kassan, Modar Cardiovasc Diabetol Review The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity perturbs the integrity of normal endothelium, leading to endothelial dysfunction which predisposes the patient to cardiovascular diseases. MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that play important roles in a variety of cellular processes such as differentiation, proliferation, apoptosis, and stress response; their alteration contributes to the development of many pathologies including obesity. Mediators of obesity-induced endothelial dysfunction include altered endothelial nitric oxide synthase (eNOS), Sirtuin 1 (SIRT1), oxidative stress, autophagy machinery and endoplasmic reticulum (ER) stress. All of these factors have been shown to be either directly or indirectly caused by gene regulatory mechanisms of miRNAs. In this review, we aim to provide a comprehensive description of the therapeutic potential of miRNAs to treat obesity-induced endothelial dysfunction. This may lead to the identification of new targets for interventions that may prevent or delay the development of obesity-related cardiovascular disease. BioMed Central 2020-09-09 /pmc/articles/PMC7488343/ /pubmed/32907629 http://dx.doi.org/10.1186/s12933-020-01107-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Ait-Aissa, Karima Nguyen, Quynh My Gabani, Mohanad Kassan, Adam Kumar, Santosh Choi, Soo-Kyoung Gonzalez, Alexis A. Khataei, Tahsin Sahyoun, Amal M. Chen, Cheng Kassan, Modar MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy |
title | MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy |
title_full | MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy |
title_fullStr | MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy |
title_full_unstemmed | MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy |
title_short | MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy |
title_sort | micrornas and obesity-induced endothelial dysfunction: key paradigms in molecular therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488343/ https://www.ncbi.nlm.nih.gov/pubmed/32907629 http://dx.doi.org/10.1186/s12933-020-01107-3 |
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