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CRISPR-mediated gene modification of hematopoietic stem cells with beta-thalassemia IVS-1-110 mutation

BACKGROUND: β-Thalassemias represent a group of genetic disorders caused by human hemoglobin beta (HBB) gene mutations. The radical curative approach is to correct the mutations causing the disease. CRISPR-CAS9 is a novel gene-editing technology that can be used auspiciously for the treatment of the...

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Detalles Bibliográficos
Autores principales:	Gabr, Hala, El Ghamrawy, Mona Kamal, Almaeen, Abdulrahman H., Abdelhafiz, Ahmed Samir, Hassan, Aya Osama Saad, El Sissy, Maha Hamdi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488347/ https://www.ncbi.nlm.nih.gov/pubmed/32912325 http://dx.doi.org/10.1186/s13287-020-01876-4

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