Discovery of the anti-angiogenesis effect of eltrombopag in breast cancer through targeting of HuR protein

HuR (human antigen R), an mRNA-binding protein responsible for poor prognosis in nearly all kinds of malignancies, is a potential anti-tumor target for drug development. While screening HuR inhibitors with a fluorescence polarization (FP) based high-throughput screening (HTS) system, the clinically...

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Detalles Bibliográficos
Autores principales: Zhu, Yuying, Yang, Liuqing, Xu, Jiazhen, Yang, Xiyan, Luan, Pengwei, Cui, Qianfei, Zhang, Pei, Wang, Feiyun, Li, Ruixiang, Ding, Xinyue, Jiang, Lixian, Lin, Guoqiang, Zhang, Jiange
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488360/
https://www.ncbi.nlm.nih.gov/pubmed/32963940
http://dx.doi.org/10.1016/j.apsb.2020.02.007

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