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Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma

Simultaneous inhibition of MDM2 and CDK4 may be an effective treatment against glioblastoma. A collection of chiral spirocyclic tetrahydronaphthalene (THN)-oxindole hybrids for this purpose have been developed. Appropriate stereochemistry in THN-fused spirooxindole compounds is key to their inhibito...

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Detalles Bibliográficos
Autores principales:	Wang, Biao, Peng, Fu, Huang, Wei, Zhou, Jin, Zhang, Nan, Sheng, Jia, Haruehanroengra, Phensinee, He, Gu, Han, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488488/ https://www.ncbi.nlm.nih.gov/pubmed/32963945 http://dx.doi.org/10.1016/j.apsb.2019.12.013

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