Design, synthesis and pharmacological evaluation of 4-(3-chloro-4-(3-cyclopropylthioureido)-2-fluorophenoxy)-7-methoxyquinoline-6-carboxamide (WXFL-152): a novel triple angiokinase inhibitor for cancer therapy

Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great success in recent years. In this study, we present...

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Detalles Bibliográficos
Autores principales: Yao, Yuqin, Liu, Zhuowei, Zhao, Manyu, Chen, Zhengxia, Li, Peng, Zhang, Yang, Wang, Yuxi, Zhao, Chengjian, Long, Chaofeng, Chen, Xiaoxin, Yang, Jinliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488503/
https://www.ncbi.nlm.nih.gov/pubmed/32963943
http://dx.doi.org/10.1016/j.apsb.2020.04.002

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