Histone Deacetylases Regulation by δ-Opioids in Human Optic Nerve Head Astrocytes

PURPOSE: We determined whether δ-opioid receptor agonist (SNC-121) regulates acetylation homeostasis via controlling histone deacetylases (HDACs) activity and expression in optic nerve head (ONH) astrocytes. METHODS: ONH astrocytes were treated with SNC-121 (1 µM) for 24 hours. The HDAC activity was...

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Detalles Bibliográficos
Autores principales: Zaidi, Syed A. H., Thakore, Nakul, Singh, Sudha, Guzman, Wendy, Mehrotra, Shikhar, Gangaraju, Vamsi, Husain, Shahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Physiology and Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488628/
https://www.ncbi.nlm.nih.gov/pubmed/32915982
http://dx.doi.org/10.1167/iovs.61.11.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488628/
https://www.ncbi.nlm.nih.gov/pubmed/32915982
http://dx.doi.org/10.1167/iovs.61.11.17

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