Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease

Alzheimer’s disease (AD) has been a devastating public health with the development of global aging. Approaches for reducing the current AD epidemic are becoming a primary focus of human healthcare due to the lack of achieved lasting and complete remission strategies to treat AD with the characterist...

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Detalles Bibliográficos
Autores principales: Guo, Mengtian, Yin, Zhenyu, Chen, Fanglian, Lei, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488700/
https://www.ncbi.nlm.nih.gov/pubmed/32928293
http://dx.doi.org/10.1186/s13195-020-00670-x
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author Guo, Mengtian
Yin, Zhenyu
Chen, Fanglian
Lei, Ping
author_facet Guo, Mengtian
Yin, Zhenyu
Chen, Fanglian
Lei, Ping
author_sort Guo, Mengtian
collection PubMed
description Alzheimer’s disease (AD) has been a devastating public health with the development of global aging. Approaches for reducing the current AD epidemic are becoming a primary focus of human healthcare due to the lack of achieved lasting and complete remission strategies to treat AD with the characteristics of heterogeneity and complexity. Exosomes, which is the new emerging approach to intercellular communication, provide novel perspective on identified therapeutic strategies of AD. Mesenchymal stem cell-derived exosomes (MSC-exos) are emerging to be an appealing therapeutic tool for AD, with the donor-derived properties and the characteristics of minimal immunogenicity, effortless storage, nature delivery vehicles, and low risks of tumor formation based on the previous researches. In this review, we elaborate the mechanism of MSC-exos in the treatment of AD and discuss limitations in the clinical application.
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spelling pubmed-74887002020-09-16 Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease Guo, Mengtian Yin, Zhenyu Chen, Fanglian Lei, Ping Alzheimers Res Ther Review Alzheimer’s disease (AD) has been a devastating public health with the development of global aging. Approaches for reducing the current AD epidemic are becoming a primary focus of human healthcare due to the lack of achieved lasting and complete remission strategies to treat AD with the characteristics of heterogeneity and complexity. Exosomes, which is the new emerging approach to intercellular communication, provide novel perspective on identified therapeutic strategies of AD. Mesenchymal stem cell-derived exosomes (MSC-exos) are emerging to be an appealing therapeutic tool for AD, with the donor-derived properties and the characteristics of minimal immunogenicity, effortless storage, nature delivery vehicles, and low risks of tumor formation based on the previous researches. In this review, we elaborate the mechanism of MSC-exos in the treatment of AD and discuss limitations in the clinical application. BioMed Central 2020-09-14 /pmc/articles/PMC7488700/ /pubmed/32928293 http://dx.doi.org/10.1186/s13195-020-00670-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Guo, Mengtian
Yin, Zhenyu
Chen, Fanglian
Lei, Ping
Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease
title Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease
title_full Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease
title_fullStr Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease
title_full_unstemmed Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease
title_short Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease
title_sort mesenchymal stem cell-derived exosome: a promising alternative in the therapy of alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488700/
https://www.ncbi.nlm.nih.gov/pubmed/32928293
http://dx.doi.org/10.1186/s13195-020-00670-x
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AT chenfanglian mesenchymalstemcellderivedexosomeapromisingalternativeinthetherapyofalzheimersdisease
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