Cargando…

No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19

There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, bu...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Georgia Wilson, Monopoli, Marco P, Campagnolo, Luisa, Pietroiusti, Antonio, Tran, Lang, Fadeel, Bengt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488724/
https://www.ncbi.nlm.nih.gov/pubmed/32873192
http://dx.doi.org/10.2217/nnm-2020-0286
_version_ 1783581752318492672
author Jones, Georgia Wilson
Monopoli, Marco P
Campagnolo, Luisa
Pietroiusti, Antonio
Tran, Lang
Fadeel, Bengt
author_facet Jones, Georgia Wilson
Monopoli, Marco P
Campagnolo, Luisa
Pietroiusti, Antonio
Tran, Lang
Fadeel, Bengt
author_sort Jones, Georgia Wilson
collection PubMed
description There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.
format Online
Article
Text
id pubmed-7488724
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Future Medicine Ltd
record_format MEDLINE/PubMed
spelling pubmed-74887242020-09-14 No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19 Jones, Georgia Wilson Monopoli, Marco P Campagnolo, Luisa Pietroiusti, Antonio Tran, Lang Fadeel, Bengt Nanomedicine (Lond) Perspective There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic. Future Medicine Ltd 2020-09-02 2020-08 /pmc/articles/PMC7488724/ /pubmed/32873192 http://dx.doi.org/10.2217/nnm-2020-0286 Text en © 2020 Bengt Fadeel This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Perspective
Jones, Georgia Wilson
Monopoli, Marco P
Campagnolo, Luisa
Pietroiusti, Antonio
Tran, Lang
Fadeel, Bengt
No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19
title No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19
title_full No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19
title_fullStr No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19
title_full_unstemmed No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19
title_short No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19
title_sort no small matter: a perspective on nanotechnology-enabled solutions to fight covid-19
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488724/
https://www.ncbi.nlm.nih.gov/pubmed/32873192
http://dx.doi.org/10.2217/nnm-2020-0286
work_keys_str_mv AT jonesgeorgiawilson nosmallmatteraperspectiveonnanotechnologyenabledsolutionstofightcovid19
AT monopolimarcop nosmallmatteraperspectiveonnanotechnologyenabledsolutionstofightcovid19
AT campagnololuisa nosmallmatteraperspectiveonnanotechnologyenabledsolutionstofightcovid19
AT pietroiustiantonio nosmallmatteraperspectiveonnanotechnologyenabledsolutionstofightcovid19
AT tranlang nosmallmatteraperspectiveonnanotechnologyenabledsolutionstofightcovid19
AT fadeelbengt nosmallmatteraperspectiveonnanotechnologyenabledsolutionstofightcovid19