Cargando…
Immune responses upon experimental Erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens
Erysipelas, a disease caused by Erysipelothrix rhusiopathiae (ER), is an increasing problem in laying hens housed in cage-free systems. This study aimed to monitor immune responses during ER infection of naïve chickens and chickens vaccinated intra muscularly with a commercial inactivated ER vaccine...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488726/ https://www.ncbi.nlm.nih.gov/pubmed/32928307 http://dx.doi.org/10.1186/s13567-020-00830-9 |
_version_ | 1783581752794546176 |
---|---|
author | Wattrang, Eva Eriksson, Helena Jinnerot, Tomas Persson, Maria Bagge, Elisabeth Söderlund, Robert Naghizadeh, Mohammad Dalgaard, Tina Sørensen |
author_facet | Wattrang, Eva Eriksson, Helena Jinnerot, Tomas Persson, Maria Bagge, Elisabeth Söderlund, Robert Naghizadeh, Mohammad Dalgaard, Tina Sørensen |
author_sort | Wattrang, Eva |
collection | PubMed |
description | Erysipelas, a disease caused by Erysipelothrix rhusiopathiae (ER), is an increasing problem in laying hens housed in cage-free systems. This study aimed to monitor immune responses during ER infection of naïve chickens and chickens vaccinated intra muscularly with a commercial inactivated ER vaccine. Chickens were infected intra muscularly with ER at 30 days of age and blood leukocyte counts, serum levels of mannose binding lectin (MBL) and ER-specific IgY were monitored until the experiment was terminated at day 15 after infection. ER was detected in blood from more chickens and at higher bacterial counts in the naïve group (day 1: 1 of 7 chickens; day 3: 6 of 6 chickens) than in the vaccinated group (day 1: 0 of 7 chickens; day 3: 1 of 6 chickens). During the acute phase of infection transient increases in circulating heterophil numbers and serum MBL levels were detected in all ER infected chickens but these responses were prolonged in chickens from the naïve group compared to vaccinated chickens. Before infection IgY titers to ER in vaccinated chickens did not differ significantly from those of naïve chickens but vaccinated chickens showed significantly increased IgY titers to ER earlier after infection compared to chickens in the naïve group. In conclusion, the ER infection elicited prompt acute innate responses in all chickens. Vaccinated chickens did not have high IgY titers to ER prior to infection but did however show lower levels of bacteraemia and their acute immune responses were of shorter duration. |
format | Online Article Text |
id | pubmed-7488726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-74887262020-09-16 Immune responses upon experimental Erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens Wattrang, Eva Eriksson, Helena Jinnerot, Tomas Persson, Maria Bagge, Elisabeth Söderlund, Robert Naghizadeh, Mohammad Dalgaard, Tina Sørensen Vet Res Research Article Erysipelas, a disease caused by Erysipelothrix rhusiopathiae (ER), is an increasing problem in laying hens housed in cage-free systems. This study aimed to monitor immune responses during ER infection of naïve chickens and chickens vaccinated intra muscularly with a commercial inactivated ER vaccine. Chickens were infected intra muscularly with ER at 30 days of age and blood leukocyte counts, serum levels of mannose binding lectin (MBL) and ER-specific IgY were monitored until the experiment was terminated at day 15 after infection. ER was detected in blood from more chickens and at higher bacterial counts in the naïve group (day 1: 1 of 7 chickens; day 3: 6 of 6 chickens) than in the vaccinated group (day 1: 0 of 7 chickens; day 3: 1 of 6 chickens). During the acute phase of infection transient increases in circulating heterophil numbers and serum MBL levels were detected in all ER infected chickens but these responses were prolonged in chickens from the naïve group compared to vaccinated chickens. Before infection IgY titers to ER in vaccinated chickens did not differ significantly from those of naïve chickens but vaccinated chickens showed significantly increased IgY titers to ER earlier after infection compared to chickens in the naïve group. In conclusion, the ER infection elicited prompt acute innate responses in all chickens. Vaccinated chickens did not have high IgY titers to ER prior to infection but did however show lower levels of bacteraemia and their acute immune responses were of shorter duration. BioMed Central 2020-09-14 2020 /pmc/articles/PMC7488726/ /pubmed/32928307 http://dx.doi.org/10.1186/s13567-020-00830-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Wattrang, Eva Eriksson, Helena Jinnerot, Tomas Persson, Maria Bagge, Elisabeth Söderlund, Robert Naghizadeh, Mohammad Dalgaard, Tina Sørensen Immune responses upon experimental Erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens |
title | Immune responses upon experimental Erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens |
title_full | Immune responses upon experimental Erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens |
title_fullStr | Immune responses upon experimental Erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens |
title_full_unstemmed | Immune responses upon experimental Erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens |
title_short | Immune responses upon experimental Erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens |
title_sort | immune responses upon experimental erysipelothrix rhusiopathiae infection of naïve and vaccinated chickens |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488726/ https://www.ncbi.nlm.nih.gov/pubmed/32928307 http://dx.doi.org/10.1186/s13567-020-00830-9 |
work_keys_str_mv | AT wattrangeva immuneresponsesuponexperimentalerysipelothrixrhusiopathiaeinfectionofnaiveandvaccinatedchickens AT erikssonhelena immuneresponsesuponexperimentalerysipelothrixrhusiopathiaeinfectionofnaiveandvaccinatedchickens AT jinnerottomas immuneresponsesuponexperimentalerysipelothrixrhusiopathiaeinfectionofnaiveandvaccinatedchickens AT perssonmaria immuneresponsesuponexperimentalerysipelothrixrhusiopathiaeinfectionofnaiveandvaccinatedchickens AT baggeelisabeth immuneresponsesuponexperimentalerysipelothrixrhusiopathiaeinfectionofnaiveandvaccinatedchickens AT soderlundrobert immuneresponsesuponexperimentalerysipelothrixrhusiopathiaeinfectionofnaiveandvaccinatedchickens AT naghizadehmohammad immuneresponsesuponexperimentalerysipelothrixrhusiopathiaeinfectionofnaiveandvaccinatedchickens AT dalgaardtinasørensen immuneresponsesuponexperimentalerysipelothrixrhusiopathiaeinfectionofnaiveandvaccinatedchickens |