Amyloid-β(1–43) cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations

BACKGROUND: Alzheimer’s disease (AD) mutations in amyloid precursor protein (APP) and presenilins (PSENs) could potentially lead to the production of longer amyloidogenic Aβ peptides. Amongst these, Aβ(1–43) is more prone to aggregation and has higher toxic properties than the long-known Aβ(1–42). H...

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Detalles Bibliográficos
Autores principales: Perrone, Federica, Bjerke, Maria, Hens, Elisabeth, Sieben, Anne, Timmers, Maarten, De Roeck, Arne, Vandenberghe, Rik, Sleegers, Kristel, Martin, Jean-Jacques, De Deyn, Peter P., Engelborghs, Sebastiaan, van der Zee, Julie, Van Broeckhoven, Christine, Cacace, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488767/
https://www.ncbi.nlm.nih.gov/pubmed/32917274
http://dx.doi.org/10.1186/s13195-020-00676-5

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