Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer’s disease mutations but not by inhibition of BACE1

BACKGROUND: Alzheimer’s disease (AD) is the most frequent and costly neurodegenerative disorder. Although diverse lines of evidence suggest that the amyloid precursor protein (APP) is involved in its causation, the precise mechanisms remain unknown and no treatments are available to prevent or halt...

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Detalles Bibliográficos
Autores principales: Johnson, Erik C. B., Ho, Kaitlyn, Yu, Gui-Qiu, Das, Melanie, Sanchez, Pascal E., Djukic, Biljana, Lopez, Isabel, Yu, Xinxing, Gill, Michael, Zhang, Weiping, Paz, Jeanne T., Palop, Jorge J., Mucke, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489007/
https://www.ncbi.nlm.nih.gov/pubmed/32921309
http://dx.doi.org/10.1186/s13024-020-00393-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489007/
https://www.ncbi.nlm.nih.gov/pubmed/32921309
http://dx.doi.org/10.1186/s13024-020-00393-5

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