Delayed Presentation of Drug-Induced Hepatic Injury

Drug-induced hepatotoxicity is a major cause of acute liver failure (ALF) in the United States. There are many offending agents like prescription drugs and herbal remedies. However, the most common prescription medication involved worldwide is amoxicillin-clavulanate. We report an unusually delayed...

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Autores principales: Ahmed, Shohana, Onteddu, Nirmal K, Jabur, Ali, Vulasala, Sai Swarupa R, Kolli, Swapna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Family/General Practice
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489320/
https://www.ncbi.nlm.nih.gov/pubmed/32944435
http://dx.doi.org/10.7759/cureus.9713
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author Ahmed, Shohana
Onteddu, Nirmal K
Jabur, Ali
Vulasala, Sai Swarupa R
Kolli, Swapna
author_facet Ahmed, Shohana
Onteddu, Nirmal K
Jabur, Ali
Vulasala, Sai Swarupa R
Kolli, Swapna
author_sort Ahmed, Shohana
collection PubMed
description Drug-induced hepatotoxicity is a major cause of acute liver failure (ALF) in the United States. There are many offending agents like prescription drugs and herbal remedies. However, the most common prescription medication involved worldwide is amoxicillin-clavulanate. We report an unusually delayed presentation of severe cholestatic hepatitis caused by amoxicillin-clavulanate in a 20-year-old female with worsening hyperbilirubinemia that was successfully treated with corticosteroids and ursodeoxycholic acid (UDCA). 
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spelling pubmed-74893202020-09-16 Delayed Presentation of Drug-Induced Hepatic Injury Ahmed, Shohana Onteddu, Nirmal K Jabur, Ali Vulasala, Sai Swarupa R Kolli, Swapna Cureus Family/General Practice Drug-induced hepatotoxicity is a major cause of acute liver failure (ALF) in the United States. There are many offending agents like prescription drugs and herbal remedies. However, the most common prescription medication involved worldwide is amoxicillin-clavulanate. We report an unusually delayed presentation of severe cholestatic hepatitis caused by amoxicillin-clavulanate in a 20-year-old female with worsening hyperbilirubinemia that was successfully treated with corticosteroids and ursodeoxycholic acid (UDCA).  Cureus 2020-08-13 /pmc/articles/PMC7489320/ /pubmed/32944435 http://dx.doi.org/10.7759/cureus.9713 Text en Copyright © 2020, Ahmed et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Family/General Practice
Ahmed, Shohana
Onteddu, Nirmal K
Jabur, Ali
Vulasala, Sai Swarupa R
Kolli, Swapna
Delayed Presentation of Drug-Induced Hepatic Injury
title Delayed Presentation of Drug-Induced Hepatic Injury
title_full Delayed Presentation of Drug-Induced Hepatic Injury
title_fullStr Delayed Presentation of Drug-Induced Hepatic Injury
title_full_unstemmed Delayed Presentation of Drug-Induced Hepatic Injury
title_short Delayed Presentation of Drug-Induced Hepatic Injury
title_sort delayed presentation of drug-induced hepatic injury
topic Family/General Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489320/
https://www.ncbi.nlm.nih.gov/pubmed/32944435
http://dx.doi.org/10.7759/cureus.9713
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AT jaburali delayedpresentationofdruginducedhepaticinjury
AT vulasalasaiswarupar delayedpresentationofdruginducedhepaticinjury
AT kolliswapna delayedpresentationofdruginducedhepaticinjury

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